Related Experiment Video

Updated: Jul 8, 2025

Characterization of Functionally Associated miRNAs in Glioblastoma and their Engineering into Artificial Clusters for Gene Therapy
09:40

Characterization of Functionally Associated miRNAs in Glioblastoma and their Engineering into Artificial Clusters for Gene Therapy

Published on: October 4, 2019

5.7K

Exploring signaling pathway crosstalk in glioma by mapping miRNA and WNT pathways: A review

Adamu Imam Isa1

  • 1Department of Physiology, College of Medicine, University of Bisha, Bisha 61922, Saudi Arabia.

International Journal of Biological Macromolecules
|December 13, 2023
PubMed

Insights

MicroRNAs (miRNAs) are key regulators in glioma development. This study analyzes how miRNAs interact with the WNT pathway to influence cancer progression, offering insights into glioma

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Glioma presents a significant healthcare challenge due to poorly understood genetic regulatory mechanisms.
  • Treatment difficulties highlight the need to elucidate molecular pathways driving glioma malignancy.
  • MicroRNAs (miRNAs) are increasingly recognized for their critical roles in cancer development by regulating signaling pathways.

Purpose of the Study:

  • To analyze the role of miRNAs in the WNT pathway in glioma.
  • To investigate the interplay between miRNAs and the WNT pathway in glioma progression.
  • To understand how this interaction influences key cellular functions relevant to cancer.

Main Methods:

  • Literature review and analysis of existing research on miRNAs and the WNT pathway in glioma.
  • Examination of miRNA targets and their involvement in WNT signaling cascades.
  • Correlation of WNT pathway and miRNA dysregulation with glioma hallmarks.

Main Results:

  • miRNAs play a critical role in regulating the WNT pathway in glioma.
  • Dysregulation of miRNAs and the WNT pathway is evident in glioma.
  • The WNT-miRNA axis influences crucial cellular processes like proliferation, invasion, migration, and epithelial-mesenchymal transition.

Conclusions:

  • miRNAs are integral components of WNT pathway dysregulation in glioma.
  • Understanding the WNT-miRNA interaction provides insights into glioma pathogenesis.
  • Targeting this axis may offer novel therapeutic strategies for glioma treatment.
Keywords:
GliomaWnt/β-catenin pathwaysmiRNAs

More Related Videos

Co-culture of Glioblastoma Stem-like Cells on Patterned Neurons to Study Migration and Cellular Interactions10:08

Co-culture of Glioblastoma Stem-like Cells on Patterned Neurons to Study Migration and Cellular Interactions

Published on: February 24, 2021

6.0K
Quantitative Immunohistochemistry of the Cellular Microenvironment in Patient Glioblastoma Resections05:45

Quantitative Immunohistochemistry of the Cellular Microenvironment in Patient Glioblastoma Resections

Published on: July 31, 2017

9.7K

Related Concept Videos

Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
6.3K
Canonical Wnt Signaling Pathway02:54

Canonical Wnt Signaling Pathway

The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which...
8.8K
Non-Canonical Wnt Signaling Pathways01:41

Non-Canonical Wnt Signaling Pathways

Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
7.3K
Hedgehog Signaling Pathway02:33

Hedgehog Signaling Pathway

The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
7.4K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
3.8K
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.0K