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Black holes in compression therapy: A quest for data
Giovanni Mosti1, Cees Wittens2, Alberto Caggiati3
1Clinica MD Barbantini, Angiology Department, Lucca, Italy.
Journal of Vascular Surgery. Venous and Lymphatic Disorders
|December 13, 2023
Summary
Compression therapy (CT) shows robust evidence for advanced venous insufficiency, deep vein thrombosis, and lymphedema. However, more high-quality studies are needed to confirm CT efficacy in other clinical scenarios.
Area of Science:
- Vascular Medicine
- Medical Technology
- Evidence-Based Practice
Background:
- Compression therapy (CT) is a cornerstone conservative treatment for chronic venous disease.
- Despite its widespread use, robust scientific evidence supporting CT is lacking for numerous clinical indications.
Purpose of the Study:
- To review the existing strong evidence for compression therapy (CT) across various clinical scenarios.
- To identify areas where high-quality research is needed to establish definitive recommendations for CT.
Main Methods:
- A comprehensive literature search was performed using MEDLINE with PubMed, Scopus, and Web of Science.
- The search encompassed articles published in English between January 1980 and October 2022.
Main Results:
- Robust data supports CT effectiveness in advanced venous insufficiency (C3-C6), deep vein thrombosis, and lymphedema.
- Evidence for venous symptom control and sports recovery exists but is limited by study quality, precluding strong recommendations.
- Insufficient or conflicting data exists for CT in postvenous procedures, superficial venous thrombosis, thromboprophylaxis, and post-thrombotic syndrome.
Conclusions:
- High-level scientific studies are essential to determine the efficacy or ineffectiveness of CT in areas with limited or contradictory data.
- Further research is crucial to guide clinical practice and optimize the application of compression therapy.

