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Allergic Reactions02:06

Allergic Reactions

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Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
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Asthma: Pathogenesis and Management01:20

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Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
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Antibody Structure01:10

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Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
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Protease Activity-Independent, Th Cell-Dependent Airway IL-33 Release Drives Eosinophilia in Mice Presensitized to Papain via SDS-Treated Skin.

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Skin Treatment with Detergent Induces Dermatitis with H1-Antihistamine-Refractory Itch and Upregulates IL-4 and Th17/Th22 Cytokine Gene Expression in C57BL/6 Mice.

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Epicutaneous challenge with protease allergen requires its protease activity to recall T<sub>H</sub>2 and T<sub>H</sub>17/T<sub>H</sub>22 responses in mice pre-sensitized via distant skin.

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Allergens in modern society: 2021.

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Updated: Jul 8, 2025

Humanized Mediator Release Assay as a Read-Out for Allergen Potency
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[ALLERGEN PROTEASE ACTIVITY PROMOTES INFLAMMATION AND SENSITIZATION]

Toshiro Takai1

  • 1Atopy (Allergy) Research Center, Juntendo University Graduate School of Medicine.

Arerugi = [Allergy]
|December 13, 2023
PubMed
Summary

No abstract available in PubMed .

Keywords:
adaptive immunityinnate immunityprotease allergen

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