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Updated: Jun 24, 2026
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Quantification of Orofacial Phenotypes in Xenopus
Published on: November 6, 2014
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Sidedness in Unilateral Orofacial Clefts: A Systematic Scoping Review
Matthew Fell1,2, Daniel Bradley3, Ambika Chadha4,5
1Spires Cleft Centre, John Radcliffe Hospital, Oxford, UK.
Summary
Research on unilateral cleft lip and palate (UCLP) sidedness reveals a left-sided predilection. While findings on causes and outcomes by cleft side are emerging, more research is needed to differentiate impacts.
Area of Science:
- Craniofacial research
- Developmental biology
- Genetics and public health
Background:
- Unilateral cleft lip with or without cleft palate (UCLP) exhibits directional asymmetry.
- Understanding the cause and impact of this asymmetry is crucial for targeted interventions.
Purpose of the Study:
- To systematically review the literature on UCLP sidedness.
- To map current knowledge regarding the causes and outcomes associated with left- versus right-sided UCLP.
Main Methods:
- Scoping review utilizing systematic searches of Medline and Embase databases.
- Inclusion of studies from inception to May 2023, focusing on humans with UCLP.
Main Results:
- Forty studies confirmed a left-sided predilection for UCLP.
- Cleft sidedness co-occurred with phenotypes like dental anomalies and handedness.
- Potential causes (chromosomal, genetic, environmental) and outcomes (facial features, growth, psychological characteristics) were investigated, with some evidence suggesting worse outcomes in right-sided UCLP.
Conclusions:
- The study of UCLP sidedness is an expanding field with early promising findings.
- Research suggests potential differences in causes and outcomes based on cleft laterality.
- Further investigation is warranted to fully elucidate the implications of UCLP sidedness.
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