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Delivery of nucleic acids using nanomaterials
Yuyang Qin1, Liyuan Ou1, Lili Zha1
1West China School of Public Health and West China Fourth Hospital, and State Key Laboratory of Biotherapy, Sichuan University, Chengdu, 610041, China.
Molecular Biomedicine
|December 13, 2023
Summary
Nucleic acid therapeutics show great promise but face delivery challenges. This review highlights advancements in nanomaterials, focusing on non-viral vectors like polymers and lipids, to improve stability and cellular uptake for effective treatments.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Pharmacology
Background:
- Nucleic acid therapeutics offer broad disease treatment potential.
- Challenges include nuclease degradation and poor cellular entry.
- Effective delivery vectors are crucial for therapeutic success.
Purpose of the Study:
- To review recent advancements in nanomaterials for nucleic acid delivery.
- To detail characteristics and applications of polymer, lipid, and hybrid vectors.
- To discuss biological barriers and strategies for organ-selective delivery.
Main Methods:
- Overview of nanomaterial-based nucleic acid delivery systems.
- Detailed analysis of polymer, lipid, and polymer-lipid hybrid vectors.
- Discussion of biological barriers and targeted delivery strategies.
Main Results:
- Non-viral vectors are prominent due to low immunogenicity and scalability.
- Polymers, lipids, and hybrids show diverse applications in nucleic acid delivery.
- Strategies for overcoming biological barriers and achieving organ selectivity are explored.
Conclusions:
- Nanomaterials are key to overcoming nucleic acid delivery challenges.
- Rational design of next-generation vectors is essential for therapeutic development.
- This review provides insights into advanced delivery vector design for nucleic acid therapeutics.
