Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

6.6K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sunlight Activated, Film Forming Polymer Based on Diazirine Grafted Polycaprolactone.

ACS applied bio materials·2026
Same author

Branched chain and glucogenic amino acids predict brown fat recruitment and metabolic clearance in adults with overweight or obesity.

American journal of physiology. Endocrinology and metabolism·2026
Same author

Integrating inflammation and nutritional status: Monocyte-to-albumin ratio as a novel prognostic marker in nasopharyngeal cancer.

Annals of the Academy of Medicine, Singapore·2026
Same author

Exploring Microalgae as a Novel Resource for Hepatocellular Carcinoma Therapy.

Molecules (Basel, Switzerland)·2026
Same author

Identification of secretory protein related biomarkers for primary biliary cholangitis based on machine learning and experimental validation.

Open life sciences·2026
Same author

A synergistic interaction between PRMT5 and LSD1 inhibitors in AML.

Science advances·2026

Related Experiment Video

Updated: Jul 8, 2025

Orthotopic Transplantation of Breast Tumors as Preclinical Models for Breast Cancer
07:45

Orthotopic Transplantation of Breast Tumors as Preclinical Models for Breast Cancer

Published on: May 18, 2020

6.1K

Dynamic altruistic cooperation within breast tumors.

Muhammad Sufyan Bin Masroni1, Kee Wah Lee1,2, Victor Kwan Min Lee1,3

  • 1Department of Pathology, Yong Loo Lin School of Medicine, National University of Singapore, Level 3 NUH Main Building, 21 Lower Kent Ridge Road, Singapore, 119077, Singapore.

Molecular Cancer
|December 14, 2023
PubMed
Summary

Cancer cells exhibit altruism, sacrificing themselves for collective benefit and contributing to chemoresistance. This social behavior, regulated by miR-125b, allows altruistic cells to persist and influences tumor evolution.

More Related Videos

Endoscopic Bilateral Nipple-sparing Mastectomy via a Single Axillary Incision with Immediate Pre-pectoral Implant-based Breast Reconstruction
13:35

Endoscopic Bilateral Nipple-sparing Mastectomy via a Single Axillary Incision with Immediate Pre-pectoral Implant-based Breast Reconstruction

Published on: May 17, 2024

2.7K
Establishment and Culture of Patient-Derived Breast Organoids
08:29

Establishment and Culture of Patient-Derived Breast Organoids

Published on: February 17, 2023

4.7K

Related Experiment Videos

Last Updated: Jul 8, 2025

Orthotopic Transplantation of Breast Tumors as Preclinical Models for Breast Cancer
07:45

Orthotopic Transplantation of Breast Tumors as Preclinical Models for Breast Cancer

Published on: May 18, 2020

6.1K
Endoscopic Bilateral Nipple-sparing Mastectomy via a Single Axillary Incision with Immediate Pre-pectoral Implant-based Breast Reconstruction
13:35

Endoscopic Bilateral Nipple-sparing Mastectomy via a Single Axillary Incision with Immediate Pre-pectoral Implant-based Breast Reconstruction

Published on: May 17, 2024

2.7K
Establishment and Culture of Patient-Derived Breast Organoids
08:29

Establishment and Culture of Patient-Derived Breast Organoids

Published on: February 17, 2023

4.7K

Area of Science:

  • Oncology
  • Evolutionary Biology
  • Game Theory

Background:

  • Social behaviors like altruism are crucial for organism survival but underexplored in cancer cells, typically viewed as competitive.
  • This study investigates altruism in breast cancer cells and its role in chemoresistance.

Purpose of the Study:

  • To elucidate the mechanisms of altruism in breast cancer cells.
  • To understand how cancer cell altruism contributes to chemoresistance and tumor evolution.

Main Methods:

  • MicroRNA profiling of patient-derived circulating tumor cells.
  • Co-culture experiments with docetaxel treatment and assessment of ecological parameters.
  • In vitro and in vivo functional studies including mass spectrometry, RNA sequencing, and mathematical modeling.

Main Results:

  • Altruistic cancer cells secrete IGFBP2 and CCL28, benefiting neighbors under taxane exposure, while undergoing cell cycle arrest.
  • miR-125b regulates these opposing processes via NF-κB signaling (IKKβ).
  • Altruistic cells regenerate epigenetically and maintain spatial organization through lateral inhibition.

Conclusions:

  • Revealed molecular mechanisms of cancer cell altruism, persistence, and spatial spread.
  • Demonstrated tumors as dynamic social systems governed by cooperation, impacting drug response.
  • Highlighted cancer cells as models for evolutionary ecology and game theory.