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Causal relationship between aspirin consumption and heart failure: a Mendelian randomization study
Wenyi Cai1, Zhang Fang1,2, Zhiqiang Tian1
1Department of Cardiology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
ESC Heart Failure
|December 14, 2023
Summary
This study suggests aspirin use may increase heart failure risk. Mendelian randomization analysis indicated a potential causal link between aspirin consumption and heart failure occurrence.
Area of Science:
- Cardiovascular Genetics
- Pharmacogenomics
- Epidemiology
Background:
- Aspirin is widely used for cardiovascular prevention.
- The causal relationship between aspirin consumption and heart failure risk remains unclear.
- Understanding this association is crucial for clinical practice and public health.
Purpose of the Study:
- To investigate the potential causal association between aspirin consumption and the risk of developing heart failure.
- To leverage genetic variants associated with aspirin use to infer causality using Mendelian randomization.
Main Methods:
- Utilized a two-sample Mendelian randomization (MR) design with summary statistics from large genome-wide association studies.
- Employed inverse variance weighted (IVW), weighted-median, and MR-Egger regression methods.
- Conducted sensitivity analyses including heterogeneity and pleiotropy tests to ensure result validity.
Main Results:
- The primary analysis (IVW method) revealed a significant positive association between genetically predicted aspirin use and heart failure risk (OR: 1.085, P=0.017).
- Other MR methods (MR-Egger, weighted-median) did not reach statistical significance.
- Sensitivity analyses indicated no significant heterogeneity or horizontal pleiotropy, supporting the robustness of the findings.
Conclusions:
- The study provides evidence supporting a potential positive causal relationship between aspirin consumption and the risk of heart failure.
- Further research may be warranted to confirm these findings and explore underlying mechanisms.
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