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Pain in Multiple System Atrophy a Systematic Review and Meta-Analysis
Nicole Campese1, Bianca Caliò1,2, Fabian Leys1
1Department of Neurology Medical University of Innsbruck Innsbruck Austria.
Movement Disorders Clinical Practice
|December 14, 2023
Summary
Pain is a common yet under-recognized issue in multiple system atrophy (MSA), affecting 67% of patients. This frequent non-motor symptom, particularly in parkinsonian MSA, often goes undertreated, highlighting a need for better detection and management strategies.
Area of Science:
- Neurology
- Clinical Research
- Systematic Review
Background:
- Pain is a frequently reported non-motor symptom in multiple system atrophy (MSA).
- This symptom remains poorly investigated in the context of MSA.
- Understanding pain in MSA is crucial for improving patient care.
Purpose of the Study:
- To assess the prevalence of pain in individuals with multiple system atrophy (MSA).
- To characterize the features and identify risk factors associated with pain in MSA.
- To evaluate the current treatment strategies for pain in MSA patients.
Main Methods:
- A systematic literature search was conducted across PubMed, Cochrane, and Web of Science databases.
- Studies published in English until September 30, 2022, were screened using PRISMA guidelines.
- Keywords included "pain," "multiple system atrophy," "MSA," and related terms. Data from 1236 MSA individuals across 13 studies were quantitatively analyzed.
Main Results:
- The pooled prevalence of pain in multiple system atrophy (MSA) was found to be 67% (95% CI: 57%-75%).
- Pain prevalence was significantly higher in MSA with parkinsonian features (76%) compared to cerebellar types (45%).
- Pain assessment methods were heterogeneous, and only half of MSA patients with pain received targeted treatment.
Conclusions:
- Pain is a prevalent but under-recognized and undertreated non-motor symptom in multiple system atrophy (MSA).
- Further research is essential to enhance pain detection and management protocols for MSA patients.
- Improving pain assessment and treatment is critical for addressing this significant non-motor feature.
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