Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

iPS Cell Differentiation

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Discordant Severity Grading in Right Ventricular Dysfunction: Prognostic Implications of Conventional Parameters versus Three-Dimensional Echocardiography-Derived Ejection Fraction.

Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography·2026

Same author

Artificial Intelligence-Based Analysis of Right Ventricular Work Is Associated with Outcomes after Transcatheter Tricuspid Valve Intervention.

Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography·2026

Same author

Exosome Biogenesis: Meta-Analysis of Intraluminal Vesicle Size Across Species.

International journal of molecular sciences·2026

Same author

The Synthesis of α-Hydroxy-Alkylphosphonate Derivatives and Evaluation of Their Cytotoxic Activity.

Pharmaceuticals (Basel, Switzerland)·2026

Same author

Predicting adverse outcomes after cardiac surgery and structural interventions: the role of right ventricular function.

Future cardiology·2026

Same author

Cytotoxic Agents by the Phosphinoylation and Thiophosphinoylation of 3‑Hydroxy-1,2,3,6-tetrahydrophosphinine 1‑Oxides as β‑Hydroxyphosphonates and -Phosphine Oxides.

ACS omega·2026

Same journal

A Preventable Congenital Heart Malformation Syndrome Caused by a Mutation in the Glycolytic Gene PFKP.

JACC. Basic to translational science·2026

Same journal

Plasma Proteomic Signatures of Left Atrial Dysfunction and Cerebral Small Vessel Disease: Elucidating Heart-Brain Connections.

JACC. Basic to translational science·2026

Same journal

Macrophage-Specific SPP1 Contributes to Pressure Overload-Induced Cardiac Dysfunction and Maladaptive Remodeling.

JACC. Basic to translational science·2026

Same journal

Increased Arrhythmic Risk in Obesity Is Transduced by Adipose Tissue-Derived Extracellular Vesicles.

JACC. Basic to translational science·2026

Same journal

Cardiac Impulse Propagation: An Integrated View.

JACC. Basic to translational science·2026

Same journal

Recognizing Early Career Translational Investigators.

JACC. Basic to translational science·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jul 8, 2025

A High-Throughput Luciferase Assay to Evaluate Proteolysis of the Single-Turnover Protease PCSK9

A High-Throughput Luciferase Assay to Evaluate Proteolysis of the Single-Turnover Protease PCSK9

Published on: August 28, 2018

PCSK9, A Promising Novel Target for Age-Related Cardiovascular Dysfunction.

Csaba Matyas^1,2, Eszter Trojnar¹, Suxian Zhao¹

¹Laboratory of Cardiovascular Physiology and Tissue Injury, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland, USA.

JACC. Basic to Translational Science

|December 14, 2023

Summary

This summary is machine-generated.

Proprotein convertase subtilisin/kexin type 9 (PCSK9) links aging to cardiovascular disease (CVD) risk. Inhibiting PCSK9 with alirocumab reduced CVD progression in aging rats, highlighting its role in cardiovascular aging.

Keywords:

NASH PCSK9 cardiovascular aging heart failure nonalcoholic steatohepatitis transcriptomics

More Related Videos

LDL Cholesterol Uptake Assay Using Live Cell Imaging Analysis with Cell Health Monitoring

LDL Cholesterol Uptake Assay Using Live Cell Imaging Analysis with Cell Health Monitoring

Published on: November 17, 2018

Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice

Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice

Published on: February 20, 2019

Related Experiment Videos

Last Updated: Jul 8, 2025

A High-Throughput Luciferase Assay to Evaluate Proteolysis of the Single-Turnover Protease PCSK9

A High-Throughput Luciferase Assay to Evaluate Proteolysis of the Single-Turnover Protease PCSK9

Published on: August 28, 2018

LDL Cholesterol Uptake Assay Using Live Cell Imaging Analysis with Cell Health Monitoring

LDL Cholesterol Uptake Assay Using Live Cell Imaging Analysis with Cell Health Monitoring

Published on: November 17, 2018

Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice

Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice

Published on: February 20, 2019

Area of Science:

Gerontology
Cardiovascular Medicine
Metabolic Diseases

Background:

Cardiovascular diseases (CVDs) are the primary cause of mortality in the elderly population.
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a key regulator of cholesterol metabolism.
The role of PCSK9 in age-related CVD remains to be fully elucidated.

Purpose of the Study:

To investigate the association between PCSK9 and age-related cardiovascular dysfunction.
To explore the relationship between PCSK9, liver health, and CVD risk in aging.
To evaluate the therapeutic potential of PCSK9 inhibition in mitigating age-related CVD.

Main Methods:

Correlative analysis of blood PCSK9 levels with age and cardiovascular function in humans and rats.
Investigation of liver tissue in a rat model to assess fatty degeneration and its link to PCSK9.
Network analysis to identify PCSK9's role in age-associated lipid alterations and intima-media thickness.
Assessment of PCSK9 inhibition using alirocumab in aging rats to observe effects on CVD progression.

Main Results:

Blood PCSK9 levels positively correlated with increasing age and cardiovascular dysfunction in both humans and rats.
Age-related fatty liver degeneration in rats correlated with elevated serum PCSK9 and impaired cardiovascular function.
Network analysis revealed PCSK9 as a significant factor in age-associated lipid changes and intima-media thickness.
Alirocumab treatment effectively reduced CVD progression in aging rats.

Conclusions:

PCSK9 plays a critical role in the development of age-related cardiovascular diseases.
PCSK9 levels are a potential biomarker for cardiovascular aging and associated metabolic dysfunction.
Targeting PCSK9 with inhibitors like alirocumab shows promise for managing age-related CVD.