Coagulation Function and Type 2 Diabetic Kidney Disease: A Real-World Observational Study.

Area of Science:

• Nephrology
• Endocrinology
• Hematology

Background:

• Type 2 diabetic kidney disease (DKD) is a serious complication of diabetes.
• The relationship between coagulation function and DKD is complex and not fully understood.

Purpose of the Study:

• To investigate the association between coagulation function markers and the risk of developing DKD.
• To identify potential biomarkers for DKD prediction.

Main Methods:

• A real-world observational study of 2,703 participants with diabetes.
• Patients were categorized into DKD and non-DKD groups.
• Propensity score matching (PSM) was used to control for confounding factors.

Main Results:

• After adjusting for multiple variables, elevated fibrinogen (FIB) and fibrinogen degradation products (FDP) were significantly associated with an increased risk of DKD.
• A nomogram prediction model for DKD was developed with good accuracy.

Conclusions:

• Increased levels of FIB and FDP are potential risk indicators for DKD.
• Coagulation function plays a significant role in the pathogenesis of DKD.