Related Experiment Video
Updated: Jul 8, 2025
23:06
The MODS method for diagnosis of tuberculosis and multidrug resistant tuberculosis
Published on: August 11, 2008
19.1K
Dermatology practice updates in mycobacterial disease
Catherine Barker1, Hesham Alshaikh2,3, Dirk Elston2
1Department of Internal Medicine, Medical University of South Carolina, Charleston, SC, USA.
International Journal of Dermatology
|December 14, 2023
Summary
Maintain vigilance for cutaneous tuberculosis and atypical mycobacteria, often waterborne. Advanced diagnostics like PCR and MALDI-TOF improve detection and treatment, especially in immunocompromised patients.
Area of Science:
- Infectious Diseases
- Microbiology
- Dermatology
Background:
- Atypical mycobacterial infections are frequently contracted via water exposure.
- Tuberculosis (TB) is endemic globally, with increasing travel and immigration necessitating awareness.
- Public water supplies can harbor mycobacteria, posing risks for surgical site infections due to inadequate sterilization.
Purpose of the Study:
- To emphasize the importance of suspecting cutaneous tuberculosis and atypical mycobacterial infections.
- To highlight advancements in diagnostic techniques for mycobacteria.
- To alert clinicians to the risks in patients on immunosuppressive therapies.
Main Methods:
- Review of common transmission routes and endemicity of mycobacterial infections.
- Discussion of improved diagnostic methods: Auramine-Rhodamine staining, Polymerase Chain Reaction (PCR), and Matrix-Assisted Laser Desorption/Ionization-Time of Flight (MALDI-TOF) mass spectrometry.
- Emphasis on clinical vigilance for at-risk populations.
Main Results:
- Mycobacteria are prevalent in water sources, contributing to infections.
- Newer diagnostic tools offer rapid detection and drug susceptibility testing for mycobacteria.
- Immunosuppressive therapies increase patient susceptibility to these infections.
Conclusions:
- Clinicians must maintain a high index of suspicion for cutaneous tuberculosis and atypical mycobacterial infections.
- Enhanced diagnostic capabilities improve patient outcomes.
- Vigilance is crucial, particularly for patients undergoing immunosuppressive treatment.
Related Concept Videos
01:28Pulmonary Tuberculosis V
180
Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
180
01:26Pulmonary Tuberculosis IV
143
Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
143
01:29Pulmonary Tuberculosis I
244
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
244
01:23Skin Diseases and Disorders
3.9K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
3.9K
01:31Pulmonary Tuberculosis III
334
Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
The first classification is based on the development of the disease, and it includes the following categories:
334
01:28Pulmonary Tuberculosis II
240
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
240