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Menstrual changes after COVID-19 vaccine administration: a systematic review
O E Santangelo1, S Provenzano, D Grigis
1Regional Health Care and Social Agency of Lodi, ASST Lodi, Lodi, Italy. provenzanosandro@hotmail.it.
European Review for Medical and Pharmacological Sciences
|December 14, 2023
Summary
COVID-19 vaccination may cause temporary menstrual cycle changes in women. These effects are generally mild, self-limiting, and resolve within 2-3 months post-vaccination.
Area of Science:
- Reproductive Health
- Vaccinology
- Public Health
Background:
- Reports of menstrual cycle alterations emerged during the COVID-19 vaccine rollout.
- Increasing frequency of these observations suggested a potential link between vaccination and menstrual changes.
Purpose of the Study:
- To systematically review and synthesize evidence on menstrual cycle changes following COVID-19 vaccination.
Main Methods:
- Systematic review conducted following Cochrane Collaboration and MOOSE guidelines.
- Searched PubMed/Medline and Scopus databases for relevant literature.
- Included 42 articles after comprehensive search and screening.
Main Results:
- COVID-19 vaccines may influence women's quality of life.
- Observed menstrual cycle changes are typically mild to moderate.
- Symptoms tend to be self-limiting.
Conclusions:
- Menstrual cycle alterations following COVID-19 vaccination are generally temporary.
- Resolution of symptoms typically occurs within 2-3 months.
- Vaccine impact on menstrual cycles appears manageable and transient.
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