Transcatheter mitral paravalvular closure: a single centre experience with techniques and outcomes

Area of Science:

• Cardiology
• Interventional Cardiology
• Medical Devices

Background:

• Paravalvular leaks (PVL) after valve replacement can cause significant morbidity and mortality.
• Symptomatic PVL often requires intervention to improve patient outcomes.
• Transcatheter techniques offer a less invasive approach to PVL management.

Purpose of the Study:

• To evaluate the safety and efficacy of transcatheter mitral paravalvular leak closure (TMPLC) in a single center.
• To assess the procedural success and clinical outcomes of TMPLC for symptomatic mitral PVL.
• To analyze the impact of TMPLC on heart failure symptoms, anemia, and overall survival.

Main Methods:

• Retrospective observational study of patients undergoing TMPLC for moderate to severe mitral PVL.
• Procedures performed by experienced operators using standardized techniques.
• Data collection included procedural success, clinical outcomes, and adverse events.

Main Results:

• Successful occlusion achieved in 91.4% of 58 defects across 45 patients.
• Clinical success rate was 75.6%, with significant improvements in ejection fraction, hemoglobin, and reduction in LDH.
• 30-day and in-hospital mortality rates were 8.9%.

Conclusions:

• TMPLC is a safe and effective treatment for symptomatic mitral PVL.
• The procedure leads to significant clinical improvement and reduced mortality.
• Single-operator TMPLC demonstrates favorable outcomes in a real-world setting.