The association of Sort1 expression with LDL subfraction and inflammation in patients with coronary artery disease
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Published on: October 12, 2017
Mehtap Atak1, Hatice Sevim Nalkiran1, Mehmet Bostan1
1Recep Tayyip Erdogan University, Rize, Turkey.
Background:
Controversial effect of sortilin on lipoprotein metabolism in the development of atherosclerosis reveals the need for more extensive research.
Objectives:
The aim of this study was to investigate the association between Sort1 gene expression and lipids, lipoprotein subfractions, and inflammation in CAD.
Methods:
The study population included 162 subjects with CAD and 49 healthy individuals. The Sort1 gene expression level was determined by qRT-PCR using Human Sortilin TaqMan Gene Expression Assays. Lipoprotein subclasses were analysed by the Lipoprint system. Serum levels of apolipoprotein and CRP were measured by autoanalyzer.
Results:
Sort1 gene expression and atherogenic subfraction (SdLDL) levels were significantly higher (p < 0.001) while atheroprotective subfraction (LbLDL) was lower in the subjects with CAD (p < 0.050). Also, increased Sort1 gene expression levels were observed in those with higher CRP values.
Conclusions:
Our findings reveal that the high Sort1 gene expression has a prominent linear relationship with both the atherogenic LDL phenotype and proinflammation, thereby might contribute to the occurrence of CAD.
