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ICBcomb: a comprehensive expression database for immune checkpoint blockade combination therapy.

Yun Xia¹, Yan Gao¹, Ming-Yu Liu¹

¹Hubei Bioinformatics and Molecular Imaging Key Laboratory, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, China.

Briefings in Bioinformatics

|December 14, 2023

Summary

This summary is machine-generated.

A new database, ICBcomb, analyzes gene expression in immune checkpoint blockade (ICB) combination therapy. This resource aids in understanding treatment mechanisms and discovering novel combination drugs for cancer immunotherapy.

Keywords:

bioinformatics cancer combination therapy database immunotherapy tumor immunology

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Area of Science:

Oncology
Immunology
Bioinformatics

Background:

Immune checkpoint blockade (ICB) is a key cancer immunotherapy, but limited response rates necessitate combination therapies.
The gene expression patterns of ICB combination therapies are not well-understood, hindering drug discovery and mechanistic insights.

Purpose of the Study:

To construct ICBcomb, a comprehensive database of gene expression profiles for ICB combination therapies.
To facilitate the analysis of gene expression, enrichment, and immune cell infiltration in ICB combination treatments.

Main Methods:

Analysis of human and mouse expression data from ICB combination therapy trials.
Development of a user-friendly web interface with modules for dataset/disease, gene, gene set, and immune cell analysis.
Comparison of expression data between groups treated with ICB, other drugs, or combinations.

Main Results:

ICBcomb integrates 1399 samples across 29 cancer types and 52 drugs.
The database offers tools for browsing expression, enrichment, and comparison results.
Functional modules enable detailed analysis of gene expression, gene sets, and immune cell infiltration.

Conclusions:

ICBcomb is the first database resource for gene expression profiles in ICB combination therapy.
The database can elucidate mechanisms of effective combination strategies and guide the discovery of new combination drugs.