A Teenage Boy With a Radiation-Induced High-Grade Astrocytoma
Kathleen Louis-Gray1, Sangeeta Khanna, Sandra Camelo-Piragua
1Departments of Neurology (KL-G, SK, JT), Pathology (SC-P), and Radiology (AC), University of Michigan, Ann Arbor, Michigan; Department of Ophthalmology and Visual Sciences (SK, JT), Kellogg Eye Center, University of Michigan, Ann Arbor, Michigan; Division of Pediatric Neurology (PR), University of Michigan, Ann Arbor, Michigan; and Baylor College of Medicine (RF, CM), Houston, Texas.
Abstract:
A 12-year-old boy developed acute headache and vomiting. MRI brain showed a partially cystic suprasellar mass. He underwent cyst fenestration, but the cyst regrew, so he underwent transcranial subtotal resection of the mass. The pathologic diagnosis was adamantinomatous craniopharyngioma. Residual tumor was treated with proton beam radiation therapy, and panhypopituitarism was treated with hormone replacement therapy, including growth hormone. Serial brain MRI scans over several years showed no evidence of tumor recurrence. But at four years after radiation, surveillance MRI showed a new focus of nonenhancing FLAIR hyperintensity in the left basal ganglia attributed to gliosis caused by radiotherapy. Seven months later, he developed progressive right hemiparesis, expressive aphasia, and blurred vision, prompting reevaluation. MRI brain showed new enhancing and T2/FLAIR hyperintense lesions in the midbrain, basal ganglia, thalamus, anterior temporal lobe, and optic tract. The abnormal regions showed low diffusivity and relatively high regional blood flow. Stereotactic biopsy disclosed a WHO Grade 4 astrocytoma, likely radiation-induced. A germline ataxia telangiectasia mutation was found in the tumor tissue. The risk of radiation-induced pediatric brain malignancies is low but may have been increased by the mutation.
