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Circulating intermediate monocytes CD14++CD16+ are increased after elective percutaneous coronary intervention.

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Intermediate monocytes increase two months after percutaneous coronary intervention (PCI), particularly with drug-eluting stents (DES). This suggests PCI strategy influences the inflammatory response post-procedure.

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Area of Science:

  • Cardiovascular Medicine
  • Immunology
  • Interventional Cardiology

Background:

  • Inflammation is key in atherosclerosis and post-percutaneous coronary intervention (PCI) complications.
  • Intermediate monocytes (CD14++CD16+) are linked to adverse cardiovascular events.
  • Monocyte subset changes after elective PCI are not well-documented.

Purpose of the Study:

  • To investigate monocyte subset and humoral responses following elective PCI.
  • To compare responses between drug-coated balloon (DCB) and drug-eluting stent (DES) groups.

Main Methods:

  • Prospective study of 30 patients undergoing elective PCI.
  • Blood samples analyzed at baseline, 4 hours, 2 weeks, and 2 months post-PCI.
  • Monocyte subsets, gene expression (CD14+ leucocytes), and humoral biomarkers were assessed.

Main Results:

  • Intermediate monocytes decreased at 4 hours, recovered at 2 weeks, and increased at 2 months post-PCI.
  • Elevated intermediate monocytes persisted at 2 months in the DES group, but not the DCB group.
  • Biomarkers IL6 and TNFα remained elevated until 2 months post-PCI.

Conclusions:

  • Elective PCI leads to a significant increase in intermediate monocytes at 2 months.
  • The PCI strategy (DES vs. DCB) may modulate the post-PCI inflammatory response.
  • Intermediate monocyte elevation post-PCI, especially with DES, warrants further investigation.