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Related Concept Videos

Role of Hippocampus in Memory01:19

Role of Hippocampus in Memory

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The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...
264

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Related Experiment Video

Updated: Jul 8, 2025

Author Spotlight: Deciphering the Long-Term Effects of Low-Level Blast Exposures in Mice
06:00

Author Spotlight: Deciphering the Long-Term Effects of Low-Level Blast Exposures in Mice

Published on: May 24, 2024

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Proteomic Changes in the Hippocampus after Repeated Explosive-Driven Blasts.

Diego Iacono1,2,3,4,5,6, Kathleen Hatch3, Erin K Murphy3

  • 1DoD/USU Brain Tissue Repository & Neuropathology Program, Uniformed Services University (USU), Bethesda, Maryland 20814, United States.

Journal of Proteome Research
|December 14, 2023
PubMed
Summary
This summary is machine-generated.

Repeated blast exposure causes molecular changes in the rat hippocampus, even without behavioral symptoms. These findings suggest an asymptomatic blast-induced molecular altered status (ABIMAS) linked to specific protein alterations.

Keywords:
asymptomatic blast-induced molecular altered statusblast wave primary effectsexplosive-driven blastshippocampusmembrane-associated guanylate kinase inverted 3 (MAGI3)repeated blast exposuretandem mass tag proteomicstraumatic brain injury

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Area of Science:

  • Neuroscience
  • Proteomics
  • Traumatic Brain Injury

Background:

  • Repeated blast-traumatic brain injury (blast-TBI) is linked to neurological and psychiatric issues in service members.
  • The precise mechanisms of blast wave-induced brain damage and consequences remain unclear.
  • Previous studies noted molecular alterations in rat brains after blast exposure.

Purpose of the Study:

  • To compare the proteomic profile of the hippocampus in rats subjected to double blast versus sham conditions using mass spectrometry.
  • To identify specific protein changes associated with repeated blast exposure in the absence of overt histopathological or behavioral alterations.

Main Methods:

  • Utilized tandem mass tag-based mass spectrometry (TMT-MS) for unbiased proteomic profiling.
  • Analyzed protein abundance differences in the hippocampus between double blast and sham rat groups.
  • Confirmed specific protein changes, such as MAGI3, using Western blotting.

Main Results:

  • Identified significant differences in protein expression within the hippocampus of double blast rats compared to sham rats.
  • TMT-MS revealed 136 up-regulated and 94 down-regulated proteins.
  • Observed novel changes, including increased MAGI3 protein levels, not previously reported in blast studies.

Conclusions:

  • Proteomic data support the existence of an asymptomatic blast-induced molecular altered status (ABIMAS).
  • Specific hippocampal protein changes occur even without apparent behavioral or histopathological damage after repeated blast exposure.
  • Findings highlight the potential for subtle molecular alterations following blast-TBI.