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Cancer Stem Cells as a Therapeutic Target: Current Clinical Development and Future Prospective
Alex Philchenkov1, Anna Dubrovska2,3,4,5,6,7,8
1RE Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine.
Stem Cells (Dayton, Ohio)
|December 14, 2023
Summary
Cancer stem cells (CSCs) are crucial for tumor growth and treatment resistance. Targeting CSCs in clinical trials shows promise for developing new cancer therapies and personalizing treatment strategies.
Area of Science:
- Oncology
- Cancer Biology
Background:
- Cancer stem cells (CSCs) play a vital role in tumor initiation, progression, and resistance to therapy.
- Identifying and targeting CSCs is a key strategy for improving cancer treatment outcomes.
Purpose of the Study:
- To review recent advancements in CSC-directed treatment approaches.
- To highlight ongoing clinical trials targeting CSCs and stemness pathways.
- To discuss the potential of CSC assays for patient stratification and personalized medicine.
Main Methods:
- Review of current literature on CSC-targeted therapies.
- Analysis of ongoing and recently completed clinical trials.
- Discussion of emerging CSC-related biomarkers and therapeutic strategies.
Main Results:
- Numerous agents targeting CSCs are under investigation in clinical trials for solid tumors and hematologic malignancies.
- Clinical trial data are essential for advancing CSC-targeted treatments.
- CSC-guided patient stratification holds potential for personalized cancer therapy.
Conclusions:
- Targeting cancer stem cells represents a promising avenue for novel cancer therapeutics.
- Clinical trials are crucial for validating CSC-directed therapies and guiding treatment selection.
- Personalized medicine approaches incorporating CSC biomarkers may enhance treatment efficacy.
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