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Updated: Jul 8, 2025

Vascular Casting of Adult and Early Postnatal Mouse Lungs for Micro-CT Imaging
Published on: June 20, 2020
An atypical airway cast.
Wincy Wing-Sze Ng1, Max Kwun-Hung Wong2
1Adult Intensive Care Unit, Queen Mary Hospital, 102 Pok Fu Lam Road, Hong Kong Special Administrative Region, China.
Severe inhalation injury caused airway obstruction in a patient with hypercapnic respiratory failure. Veno-venous extracorporeal membrane oxygenation (VV-ECMO) successfully supported the removal of airway casts.
Area of Science:
- Pulmonology
- Critical Care Medicine
- Emergency Medicine
Background:
- Smoke inhalation can lead to severe airway injury.
- Decompensated hypercapnic respiratory failure presents a critical challenge.
- Airway obstruction from slough and pseudomembrane formation is a rare but serious complication.
Purpose of the Study:
- To report a case of severe inhalation injury with airway cast formation.
- To highlight the utility of veno-venous extracorporeal membrane oxygenation (VV-ECMO) in managing such cases.
- To demonstrate successful airway cast removal with VV-ECMO support.
Main Methods:
- A 60-year-old male patient with smoke inhalation underwent intubation.
- Fiberoptic bronchoscopy identified obstructive airway slough and pseudomembrane.
- Veno-venous extracorporeal membrane oxygenation (VV-ECMO) was initiated for stabilization.
- Airway casts were removed during the VV-ECMO support.
Main Results:
- The patient presented with decompensated hypercapnic respiratory failure post-smoke inhalation.
- Bronchoscopy confirmed severe inhalation injury manifesting as airway casts.
- VV-ECMO provided essential hemodynamic and respiratory support.
- Successful removal of the obstructive airway casts was achieved.
Conclusions:
- Airway cast formation is a critical complication of severe smoke inhalation.
- VV-ECMO is a valuable tool for stabilizing patients with severe airway obstruction.
- Periprocedural VV-ECMO facilitates successful intervention for life-threatening airway casts.
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