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Updated: Jul 17, 2026

Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation
Published on: May 2, 2013
Dupilumab-induced psoriasiform dermatitis in two pediatric cardiac transplant patients
Trevor Lockard1, Sarah A Mullen1, Erica B Lee2
1College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Abstract:
Dupilumab is an interleukin-4 receptor antagonist important in the treatment of refractory atopic dermatitis (AD), particularly among pediatric patients. Two boys with a history of AD and cardiac transplant who developed psoriasiform dermatitis in response to dupilumab therapy are reported. These patients paradoxically developed an immune-mediated adverse drug reaction despite taking systemic immunosuppressive agents. While the literature suggests possible pathomechanisms for psoriasiform dermatitis despite immunosuppression, further research is necessary to better characterize this unique and unexpected phenomenon.
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