Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Special Features of Adaptive Immunity01:20

Special Features of Adaptive Immunity

829
The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
829
Diversity of Antigen Receptors01:28

Diversity of Antigen Receptors

595
Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
595
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

994
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
994
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

68.3K
Overview
68.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

ABCC1 protects skin dendritic cells from FITC-induced toxicity by efflux and extracellular glutathione buffering.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Platelet-derived integrin- and tetraspanin-enriched tethers exacerbate severe inflammation.

Science (New York, N.Y.)·2026
Same author

Mapping cellular contacts in situ.

Nature chemical biology·2025
Same author

A distinct priming phase regulates CD8 T cell immunity by orchestrating paracrine IL-2 signals.

Science (New York, N.Y.)·2025
Same author

Oxidative phosphorylation is a key feature of neonatal monocyte immunometabolism promoting myeloid differentiation after birth.

Nature communications·2025
Same author

Ablation of CCL17-positive hippocampal neurons induces inflammation-dependent epilepsy.

Epilepsia·2024

Related Experiment Video

Updated: Jul 8, 2025

Author Spotlight: A Model to Study the Systemic and Local Dynamics of CD8+ T Cells During LN Metastasis
07:45

Author Spotlight: A Model to Study the Systemic and Local Dynamics of CD8+ T Cells During LN Metastasis

Published on: January 26, 2024

1.9K

Same yet different - how lymph node heterogeneity affects immune responses.

Paulina Cruz de Casas1, Konrad Knöpper2,3, Rupak Dey Sarkar1

  • 1Max Planck Research Group, Würzburg Institute of Systems Immunology, Julius-Maximilians-Universität Würzburg, Würzburg, Germany.

Nature Reviews. Immunology
|December 14, 2023
PubMed
Summary

Lymph nodes, crucial for adaptive immunity, exhibit functional differences. This review explores lymph node heterogeneity and its impact on immune responses, vaccination, and cancer immunotherapy.

More Related Videos

Visualizing Lymph Node Structure and Cellular Localization using Ex-Vivo Confocal Microscopy
07:40

Visualizing Lymph Node Structure and Cellular Localization using Ex-Vivo Confocal Microscopy

Published on: August 9, 2019

13.3K
Enrichment and Characterization of the Tumor Immune and Non-immune Microenvironments in Established Subcutaneous Murine Tumors
08:32

Enrichment and Characterization of the Tumor Immune and Non-immune Microenvironments in Established Subcutaneous Murine Tumors

Published on: June 7, 2018

9.6K

Related Experiment Videos

Last Updated: Jul 8, 2025

Author Spotlight: A Model to Study the Systemic and Local Dynamics of CD8+ T Cells During LN Metastasis
07:45

Author Spotlight: A Model to Study the Systemic and Local Dynamics of CD8+ T Cells During LN Metastasis

Published on: January 26, 2024

1.9K
Visualizing Lymph Node Structure and Cellular Localization using Ex-Vivo Confocal Microscopy
07:40

Visualizing Lymph Node Structure and Cellular Localization using Ex-Vivo Confocal Microscopy

Published on: August 9, 2019

13.3K
Enrichment and Characterization of the Tumor Immune and Non-immune Microenvironments in Established Subcutaneous Murine Tumors
08:32

Enrichment and Characterization of the Tumor Immune and Non-immune Microenvironments in Established Subcutaneous Murine Tumors

Published on: June 7, 2018

9.6K

Area of Science:

  • Immunology
  • Lymphatic System Biology

Background:

  • Lymph nodes are key secondary lymphoid organs regulating adaptive immune responses.
  • They receive lymph containing cellular products, pathogens, and immune cells, informing them about organ status.
  • Emerging evidence suggests functional variations exist among individual lymph nodes.

Purpose of the Study:

  • To review the structure and function of the lymphatic system.
  • To focus on factors contributing to functional heterogeneity among lymph nodes.
  • To discuss the implications of lymph node heterogeneity for immunity and disease.

Main Methods:

  • Literature review of lymphatic system structure and function.
  • Analysis of factors causing functional differences between lymph nodes.
  • Discussion of impacts on immune responses and clinical applications.

Main Results:

  • The lymphatic system's structure facilitates continuous monitoring of organ status.
  • Various factors contribute to functional heterogeneity among lymph nodes.
  • This heterogeneity influences cellular and humoral immune responses.

Conclusions:

  • Understanding lymph node heterogeneity is crucial for optimizing immune responses.
  • Lymph node differences have significant implications for vaccination strategies.
  • Targeting lymph node heterogeneity may improve cancer immunotherapy outcomes.