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Association of serum Asprosin concentrations with heart failure
Guoan Wang1,2, Chunzhen Fan3, Yaru Chai2
1School of Medicine and Pharmacy, Ocean University of China, Qingdao, Shandong, China.
Insights
Serum Asprosin levels are significantly higher in heart failure (HF) patients and are an independent risk factor for HF. Combined detection with NT-proBNP improves HF diagnosis accuracy.
Area of Science:
- Biochemistry
- Cardiology
- Biomarkers
Background:
- Heart failure (HF) is a complex clinical syndrome with significant morbidity and mortality.
- Identifying novel biomarkers for HF diagnosis and risk stratification is crucial.
Purpose of the Study:
- To investigate the association between serum Asprosin concentrations and the presence of heart failure.
- To determine if serum Asprosin is an independent risk factor for HF.
Main Methods:
- Serum Asprosin levels were measured in 103 HF patients and 103 healthy controls.
- Clinical data, including NT-ProBNP and left ventricular ejection fraction (LVEF), were collected.
- Logistic regression analysis was used to identify independent risk factors.
Main Results:
- Serum Asprosin concentrations were significantly elevated in the HF group compared to the non-HF group (P < 0.001).
- HF prevalence increased with higher serum Asprosin levels.
- Asprosin levels correlated positively with NT-ProBNP and negatively with LVEF.
- Asprosin and age were identified as independent risk factors for HF.
Conclusions:
- Elevated serum Asprosin levels are associated with heart failure.
- Serum Asprosin serves as an independent risk factor for HF.
- Combining Asprosin and NT-proBNP measurements enhances the diagnostic accuracy for HF.
Background:
To analyze the association of serum Asprosin concentrations with heart failure (HF).
Methods:
A total of 103 patients with HF were included in the HF group, and 103 patients with health checkups were included in the non-HF group. The serum Asprosin levels of the two groups were measured, and relevant clinical data were collected for statistical analysis.
Results:
Compared with the non-HF group, the serum Asprosin concentration was significantly higher in the HF group, and the difference was statistically significant (P < 0.001). According to the serum Asprosin levels, we divided all the subjects into three quartiles. We found that the prevalence of HF increased with increasing serum Asprosin levels in the three groups (P < 0.001). Serum Asprosin levels were positively correlated with NT-ProBNP (P < 0.05) and negatively correlated with LVEF (P < 0.001). Dichotomous logistic regression analysis found Asprosin and age to be independent risk factors for HF (OR = 1.010, 95% CI: 1.003-1.018; OR = 1.058, 95% CI:1.004-1.665, respectively). Combining Asprosin and NT-proBNP indicators to draw ROC curves can improve the specificity and sensitivity of HF diagnosis.
Conclusions:
Serum Asprosin levels were significantly elevated in HF patients. The serum Asprosin level is an independent risk factor for HF, and the combined detection of Asprosin and NT-proBNP levels can improve the accuracy of HF diagnosis.
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