Selecting patient-reported outcome measures for a patient-facing technology

Area of Science:

• Oncology
• Digital Health
• Patient-Reported Outcomes

Background:

• Oral anticancer agents are increasingly used for breast cancer (BCA) treatment.
• Patient-facing technology (PFT) platforms require robust methods for collecting patient-reported outcome measures (PROMs).
• Selecting appropriate PROMs is essential for accurately assessing symptoms and quality of life in BCA patients.

Purpose of the Study:

• To outline a systematic process for selecting PROMs for BCA patients undergoing oral anticancer agent treatment.
• To provide guidance on choosing PROMs suitable for integration into patient-facing technology (PFT) platforms.
• To balance patient needs with developer considerations for efficient PROM implementation.

Main Methods:

• A thorough assessment of available PROMs was conducted following established guidelines.
• PROMs were evaluated based on their content relevance for breast cancer patients.
• Considerations for PFT platform design, including interface feasibility and user workload, were incorporated.

Main Results:

• For a dedicated breast cancer application, the combination of EORTC QLQ-C30 and EORTC QLQ-BR45 is recommended.
• For multi-cancer PFT platforms, PRO-CTCAE and PROMIS 10 GH are suggested due to interface and workload considerations.
• The addition of ad hoc items to complement selected PROMs is advised for comprehensive data collection.

Conclusions:

• The selection of PROMs for PFT platforms requires careful consideration of specific cancer types and platform scope.
• The recommended PROMs aim to optimize data collection while minimizing patient and developer burden.
• This guidance assists PFT developers in navigating the complexities of PROM selection for oncology patient populations.