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Author Spotlight: Non-Surgical Treatment of Melasma– Microneedling with Tranexamic Acid
Published on: January 19, 2024
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Topical and Systemic Therapies in Melasma: A Systematic Review.
Rashmi Sarkar1, Evangeline B Handog2, Anupam Das3
1Department of Dermatology, Lady Hardinge Medical College, New Delhi, India.
Indian Dermatology Online Journal
|December 15, 2023
Summary
This review highlights effective melasma treatments, recommending hydroquinone, triple combination creams, and sunscreens. Oral tranexamic acid is strongly advised when safe, offering new options for this distressing skin condition.
Area of Science:
- Dermatology
- Cosmetic Science
Background:
- Melasma is a chronic hyperpigmentation disorder affecting quality of life.
- Conventional treatments include hydroquinone, triple combination creams, chemical peels, and laser therapy.
Purpose of the Study:
- To systematically review topical and systemic treatments for melasma.
- To provide evidence-based recommendations for melasma management.
Main Methods:
- Systematic search of PubMed and EMBASE databases up to May 4, 2021.
- Included 174 randomized controlled trials and controlled clinical trials based on PRISMA protocol.
Main Results:
- Hydroquinone (HQ), triple combination creams (TCCs), sunscreens, kojic acid (KA), and azelaic acid received a Grade A recommendation.
- Oral tranexamic acid (TXA) has a strong recommendation if no contraindications exist.
- Further research is needed for topical vitamin C, resorcinol, and topical TXA efficacy.
Conclusions:
- Newer topical and systemic agents offer innovative treatment modalities for melasma.
- Individualized treatment selection based on patient factors and availability is crucial.
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