A Case of Primary Cutaneous CD4+ Small/Medium T-Cell Lymphoproliferative Disorder

Area of Science:

• Dermatology
• Hematology
• Oncology

Background:

• Primary cutaneous CD4+ small/medium T-cell lymphoproliferative disorder (PC-TCL) is a rare skin condition.
• It exhibits indolent behavior with uncertain malignant potential.
• Histologically characterized by CD4+ T-cells expressing follicular helper markers.

Observation:

• A 59-year-old female presented with a 3-year history of nodules on her left chest.
• Dermatological examination revealed four red, non-tender nodules with angiotelectasis.
• Histopathological findings confirmed PC-TCL.

Findings:

• The case highlights the typical clinical presentation of PC-TCL.
• Histopathology confirmed a predominance of small to medium-sized CD4+ pleomorphic T-cells.
• The diagnosis was established based on characteristic histopathological features.

Implications:

• Accurate diagnosis of PC-TCL is crucial due to its indolent nature.
• Understanding clinical and histopathological features aids in differential diagnosis.
• Further research may clarify the malignant potential of PC-TCL.