Structural networking of the developing brain: from maturation to neurosurgical implications

Area of Science:

• Neuroscience
• Developmental Neuroscience
• Pediatric Neurosurgery

Background:

• Neurological processing arises from complex brain networks (connectomes).
• Brain connectome development is crucial for neurocognitive development and pediatric diseases.
• A gap exists between connectome research and pediatric neurosurgical practice.

Purpose of the Study:

• To bridge the gap between brain connectome research and pediatric neurosurgery.
• To review current knowledge on brain network maturation and its role in development and disease.
• To explore implications for neurosurgical interventions in pediatric conditions.

Main Methods:

• Literature review of neuroimaging studies on the brain connectome.
• Synthesis of current knowledge on brain network development and neurocognition.
• Analysis of connectome implications for pediatric neurosurgery.

Main Results:

• The brain connectome is a dynamic network essential for neurological function.
• Connectome maturation influences normal neurocognitive development and disease pathophysiology.
• Understanding the connectome can enhance neurosurgical approaches for pediatric epilepsy and tumors.

Conclusions:

• Integrating connectome knowledge into pediatric neurosurgery is vital for improving patient outcomes.
• Future research should focus on the clinical applications of connectome studies in pediatric neurosurgery.
• This review highlights the potential of connectome insights to advance pediatric neurosurgical care.