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Genome-wide DNA methylation changes upon DOT1L inhibition in hormone-responsive breast cancer cells

Giorgio Giurato1,2, Ilaria Terenzi1, Francesco Chiuso3

  • 1Laboratory of Molecular Medicine and Genomics, Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, Baronissi, Italy.

Frontiers in Cell and Developmental Biology
|December 15, 2023
PubMed
Abstract

No abstract available in PubMed .

Keywords:
DOT1lbreast cancerepigeneticsestrogen receptor alphamethylationreduced representation bisulfite sequencing

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Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
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