Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Multipotency and Niche of Bulge Stem Cell01:06

Multipotency and Niche of Bulge Stem Cell

3.6K
A hair follicle or HF is a small part of the skin that produces the hair shaft. Paul Gerson Unna was the first to observe a bulge in the human hair follicle's outer root sheath (ORS). The bulge is present between the sebaceous gland and the arrector pili muscle and is the niche for hair follicle stem cells (HFSCs). The bulge is also a niche for melanocyte stem cells, and their loss results in graying of hair. The HFSCs express Sox9 and Lhx2, which help them maintain stemness and prevent...
3.6K
Aging01:26

Aging

54
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
54
Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

2.0K
The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
2.0K
Human Genetics01:28

Human Genetics

583
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
583
Humanistic Psychology01:24

Humanistic Psychology

1.1K
Humanistic psychology emerged in the mid-20th century as a response to the deterministic and pessimistic nature of behaviorism and psychoanalysis. While behaviorism focused on observable behaviors influenced by the environment and psychoanalysis delved into unconscious motivations, both theories suggested that human actions lacked free will. In contrast, humanistic psychology offers a perspective that emphasizes the innate potential for goodness and growth within every individual.
This approach...
1.1K
Pigmentation01:19

Pigmentation

2.4K
The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
2.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Driver mutations and tumor mutational burden impact stage IV melanoma survival.

Journal of the American Academy of Dermatology·2026
Same author

Use of ancillary studies in pediatric spitzoid neoplasms: A retrospective cohort study.

Journal of the American Academy of Dermatology·2026
Same author

Topical cantharidin use in dermatology: an updated review.

Dermatology online journal·2025
Same author

Clinical Utility of a Digital Dermoscopy Image-Based Artificial Intelligence Device in the Diagnosis and Management of Skin Cancer by Dermatologists.

Cancers·2024
Same author

Pseudoangiosarcoma and cutaneous collagenous vasculopathy in a patient on a Bruton's tyrosine kinase inhibitor.

JAAD case reports·2024
Same author

Therapeutic modulation of KIT ligand in melanocytic disorders with implications for mast cell diseases.

Experimental dermatology·2024
Same journal

An Integrated Skin Cell Atlas Decodes the Pilosebaceous Unit.

The Journal of investigative dermatology·2026
Same journal

Residual CSB activity explains mild UV-sensitive syndrome phenotype caused by CSB mutations.

The Journal of investigative dermatology·2026
Same journal

Charting a new melanoma risk factor: Satellite Naevus Prevalence in High-Risk and Population-Based Cohorts.

The Journal of investigative dermatology·2026
Same journal

Human keratinocytes and fibroblasts coordinate early cutaneous innate defenses against Candida auris.

The Journal of investigative dermatology·2026
Same journal

Merkel cells attenuate autoantigen-specific T cell driven skin inflammation in mice associated with reduced neutrophil recruitment.

The Journal of investigative dermatology·2026
Same journal

The response of human melanocytic nevi to simulated solar radiation assessed by single-nucleus RNA sequencing of frozen tissue.

The Journal of investigative dermatology·2026
See all related articles

Related Experiment Video

Updated: Jul 8, 2025

A New Technique for Quantitative Analysis of Hair Loss in Mice Using Grayscale Analysis
06:41

A New Technique for Quantitative Analysis of Hair Loss in Mice Using Grayscale Analysis

Published on: March 9, 2015

9.0K

Human Hair Graying Revisited: Principles, Misconceptions, and Key Research Frontiers.

Ralf Paus1, Alec Sevilla2, James M Grichnik3

  • 1Dr. Phillip Frost Department of Dermatology & Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA; CUTANEON - Skin & Hair Innovations, Hamburg, Germany; Monasterium Laboratory, Münster, Germany.

The Journal of Investigative Dermatology
|December 15, 2023
PubMed
Summary
This summary is machine-generated.

Hair graying results from oxidative damage, cellular senescence, and reduced pigment production. While often irreversible, some factors indicate potential for temporary hair repigmentation strategies.

Keywords:
Hair follicle agingHair follicle pigmentary unitMelanocyte senescenceMelanogenesisRepigmentation

More Related Videos

Isolation and Culture of Adult Epithelial Stem Cells from Human Skin
08:26

Isolation and Culture of Adult Epithelial Stem Cells from Human Skin

Published on: March 31, 2011

28.4K
Collecting Hair Samples for Hair Cortisol Analysis in African Americans
06:01

Collecting Hair Samples for Hair Cortisol Analysis in African Americans

Published on: June 10, 2018

18.1K

Related Experiment Videos

Last Updated: Jul 8, 2025

A New Technique for Quantitative Analysis of Hair Loss in Mice Using Grayscale Analysis
06:41

A New Technique for Quantitative Analysis of Hair Loss in Mice Using Grayscale Analysis

Published on: March 9, 2015

9.0K
Isolation and Culture of Adult Epithelial Stem Cells from Human Skin
08:26

Isolation and Culture of Adult Epithelial Stem Cells from Human Skin

Published on: March 31, 2011

28.4K
Collecting Hair Samples for Hair Cortisol Analysis in African Americans
06:01

Collecting Hair Samples for Hair Cortisol Analysis in African Americans

Published on: June 10, 2018

18.1K

Area of Science:

  • Dermatology and aging research
  • Human pigmentation studies
  • Hair follicle biology

Background:

  • Hair graying is a visible aging hallmark with psychosocial impact.
  • It involves complex interactions of oxidative stress, DNA damage, and cellular senescence.
  • Melanocyte stem cell depletion ultimately leads to irreversible graying.

Purpose of the Study:

  • To elucidate the multifaceted mechanisms driving hair graying.
  • To identify key regulators and cellular processes involved in hair pigmentation.
  • To explore potential pathways for reversing or preventing hair graying.

Main Methods:

  • Review and synthesis of current scientific literature on hair graying.
  • Analysis of molecular and cellular factors influencing melanogenesis and melanocyte survival.
  • Examination of the hair follicle cycle's role in pigmentation and graying reversibility.

Main Results:

  • Hair graying stems from cumulative damage, mTORC1 hyperactivity, melanocyte senescence, and insufficient pigment factors.
  • Genetic factors, signaling pathways, and autophagic flux significantly modulate the process.
  • Reduced melanogenesis and defective melanosome transfer contribute to pigment loss.
  • Graying is reversible when melanocyte stem cells remain viable, with potential therapeutic targets identified.

Conclusions:

  • Hair graying is a complex process influenced by aging, genetics, and environmental factors.
  • Understanding the hair follicle microenvironment and cell cycle is crucial for addressing graying.
  • Targeting specific pathways offers potential for future anti-graying strategies, with caution advised for mouse model extrapolation.