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Conjugated Proteins02:50

Conjugated Proteins

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Simple proteins and protein complexes contain only amino acids. In contrast, many other proteins, called conjugated proteins, covalently bond with non-protein moieties.
Nucleoproteins are protein complexes that contain nucleic acids, categorized as deoxyribonucleoproteins (DNPs) or ribonucleoproteins (RNPs) respectively. The nucleosome is a typical example of a DNP where nuclear DNA is associated with histone proteins. The major antigen for the Covid-19 virus SARS-CoV is an RNP that is critical...
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C60-based Multivalent Glycoporphyrins Inhibit SARS-CoV-2 Specific Interaction with the DC-SIGN Transmembrane

Jennifer Patino-Alonso1, Justo Cabrera-González1,2, Javier Merino1

  • 1Departamento de Química Orgánica, Facultad de Química, Universidad Complutense, Madrid, E-28040, Spain.

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|December 15, 2023
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Summary
This summary is machine-generated.

Researchers developed novel nanostructures to block DC-SIGN, an important receptor for Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) infection. These glycomimetics achieved up to 90% inhibition of viral trans-infection, offering a promising therapeutic strategy.

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Area of Science:

  • Nanotechnology
  • Virology
  • Biochemistry

Background:

  • The COVID-19 pandemic, caused by SARS-CoV-2, has led to millions of deaths globally.
  • While ACE2 is the primary SARS-CoV-2 receptor, other molecules like DC-SIGN facilitate viral entry.
  • DC-SIGN acts as a trans-receptor, making it a potential target for antiviral therapies.

Purpose of the Study:

  • To design and synthesize novel multivalent nanostructures for targeting DC-SIGN-mediated SARS-CoV-2 infection.
  • To evaluate the efficacy of these nanostructures in inhibiting viral trans-infection.
  • To investigate the binding interactions between the nanostructures and the DC-SIGN receptor.

Main Methods:

  • Synthesis of glycosylated [60]fullerenes linked to a porphyrin scaffold.
  • Testing nanostructures for inhibition of DC-SIGN-mediated SARS-CoV-2 trans-infection.
  • Utilizing microscopy, NMR, Quartz Crystal Microbalance, and molecular dynamics simulations to study nanostructure-receptor binding.

Main Results:

  • The designed nanostructures demonstrated outstanding inhibition of SARS-CoV-2 trans-infection, reaching up to 90%.
  • Detailed biophysical and computational analyses provided insights into the nanostructure-receptor binding mechanisms.
  • The study confirmed the potential of targeting DC-SIGN with glycomimetics.

Conclusions:

  • Multivalent nanostructures based on glycosylated fullerenes are effective inhibitors of DC-SIGN-mediated SARS-CoV-2 infection.
  • This approach offers a promising strategy for developing new antiviral therapies against SARS-CoV-2.
  • Further research into nanostructure-receptor interactions can guide the development of more potent antiviral agents.