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Building a vertebra: Development of the amniote sclerotome
Margarethe Draga1, Martin Scaal1
1Faculty of Medicine and University Hospital Cologne, Center of Anatomy, University of Cologne, Cologne, Germany.
Abstract:
In embryonic development, the vertebral column arises from the sclerotomal compartment of the somites. The sclerotome is a mesenchymal cell mass which can be subdivided into several subpopulations specified by different regulatory mechanisms and giving rise to different parts of the vertebrae like vertebral body, vertebral arch, ribs, and vertebral joints. This review gives a short overview on the molecular and cellular basis of the formation of sclerotomal subdomains and the morphogenesis of their vertebral derivatives.
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