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Glycocalyx-inspired dynamic antifouling surfaces for temporary intravascular devices
Wentai Zhang1, Linxian Cui2, Chaoming Xie3
1Dongguan Key Laboratory of Smart Biomaterials and Regenerative Medicine, Department of Cardiology, The Tenth Affiliated Hospital, Southern Medical University, Dongguan, Guangdong, 523000, China.
Biomaterials
|December 15, 2023
Summary
A novel dynamic antifouling surface inspired by the endothelial glycocalyx prevents protein and cell adhesion on medical devices. This strategy reduces thrombosis and tissue embedment, improving device performance and retrieval.
Area of Science:
- Biomaterials Science
- Surface Engineering
- Medical Device Technology
Background:
- Protein and cell adhesion on intravascular devices cause thrombosis and embedment, leading to complications.
- Current antifouling strategies face limitations in long-term effectiveness and biofouling removal.
Purpose of the Study:
- To develop an endothelial glycocalyx-inspired dynamic antifouling surface for temporary intravascular devices.
- To prevent thrombosis and suppress intimal embedment using a novel surface strategy.
Main Methods:
- Dense grafting of hydrolyzable hyaluronic acid (HA) onto device surfaces using a phenol-polyamine platform.
- Creating a super-hydrophilic surface with dynamic, degrading antifouling properties.
Main Results:
- The HA-coated surfaces demonstrated potent antifouling against proteins and cells.
- Coated catheters showed sustained anti-thrombosis capacity after 30 days of immersion.
- Implants exhibited inhibition of intimal embedment in vivo for up to 2 months.
Conclusions:
- The glycocalyx-inspired dynamic antifouling surface strategy is effective for temporary intravascular devices.
- This approach offers a promising solution for reducing complications associated with medical implants.
- The dynamic degradation mechanism aids in the removal of biofouling, enhancing device performance.
