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Daratumumab for autoimmune diseases: a systematic review
Marie-Therese Holzer1, Nikolas Ruffer2, Tobias B Huber3
1Division of Rheumatology and Systemic Inflammatory Diseases, III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany m.holzer@uke.de.
RMD Open
|December 15, 2023
Summary
Daratumumab, a CD38-targeting antibody, shows promise for refractory autoimmune diseases, with 81% of patients experiencing remission or improvement. Further clinical trials are needed to optimize its use and manage side effects.
Area of Science:
- Immunology
- Rheumatology
- Pharmacology
Background:
- Refractory autoimmune diseases pose significant clinical challenges.
- Novel therapeutic strategies are essential for managing these conditions.
Conclusions:
- CD38-targeting with daratumumab presents a promising therapeutic avenue for refractory autoimmune diseases.
- Further research is required to determine optimal treatment regimens and manage adverse events.
- Systematic clinical trials are necessary to validate this therapeutic approach.
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