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Related Concept Videos

Stem Cell Culture01:17

Stem Cell Culture

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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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Stem Cell Therapy for Tissue Regeneration01:21

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
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Embryonic Stem Cells00:57

Embryonic Stem Cells

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Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
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Induced Pluripotent Stem Cells01:13

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Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
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iPS Cell Differentiation01:22

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The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
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High Throughput Characterization of Adult Stem Cells Engineered for Delivery of Therapeutic Factors for Neuroprotective Strategies
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Engineered stem cells by emerging biomedical stratagems.

Jinglin Wang1, Xiaoxuan Zhang2, Hanxu Chen2

  • 1Department of Vascular Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210008, China; Division of Hepatobiliary Surgery and Transplantation Surgery, Department of General Surgery, Nanjing Drum Tower Hospital, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China.

Science Bulletin
|December 15, 2023
PubMed
Summary
This summary is machine-generated.

Engineered stem cells enhance therapeutic potential for intractable disorders. This review details advancements in stem cell engineering, applications, and future clinical translation prospects.

Keywords:
BiomaterialsBioprintingGenetic modificationMicrofluidicsOrgan-on-a-chipStem cells

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Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Cell Biology

Background:

  • Stem cell therapy shows promise for intractable disorders, with established safety in clinical trials.
  • Current stem cell therapies have limitations in therapeutic benefits and clinical research data stability.
  • Engineering approaches are crucial for optimizing stem cell effectiveness and developing next-generation therapies.

Purpose of the Study:

  • To provide a comprehensive analysis of engineered stem cells.
  • To review recent advances in stem cell production and engineering strategies.
  • To discuss clinical applications, challenges, and future prospects of engineered stem cells.

Main Methods:

  • Review of recent scientific literature on stem cell engineering.
  • Analysis of advancements in stem cell production, including induced pluripotent stem cells (iPSCs), embryonic stem cells (ESCs), mesenchymal stem cells (MSCs), and hematopoietic stem cells (HSCs).
  • Examination of engineered strategies in molecular biology and biomaterial fields.

Main Results:

  • Detailed overview of engineered stem cell strategies and their applications in biomedical research.
  • Exploration of clinical applications and potential future developments.
  • Identification of current obstacles and future directions for engineered stem cells.

Conclusions:

  • Engineered stem cells represent a significant advancement in overcoming limitations of traditional stem cell therapy.
  • Further research and development in engineering techniques are essential for successful clinical translation.
  • Engineered stem cells hold substantial promise for treating a wide range of diseases and advancing biomedical applications.