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Updated: Jul 8, 2025

Measurements of Physiological Stress Responses in C. Elegans
Published on: May 21, 2020
Unlocking the plant ER stress code: IRE1-proteasome signaling cohort takes the lead
Vishal Varshney1, Jawahar Singh2, Vishnu Mishra3
1Department of Botany, Govt. Shaheed Gend Singh College, Charama, Chhattisgarh, India.
Abstract:
In the intricate landscape of cellular function, proper protein folding is pivotal for cellular processes, particularly within the endoplasmic reticulum (ER). In a recent study, Ko et al. reveal a signaling role for inositol-requiring enzyme 1 (IRE1) in ER stress and identify PHOSPHATASE TYPE 2CA (PP2CA)-INTERACTING RING FINGER PROTEIN 1 (PIR1) as a crucial plant-specific regulator, balancing the unfolded protein response (UPR) and ubiquitin-proteasome system (UPS) by modulating ABI5 stability, unveiling intricate stress response connections.
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