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Transcription factor-mediated direct cellular reprogramming yields cell-type specific DNA methylation signature

Kenichi Horisawa1, Shizuka Miura1, Hiromitsu Araki2

  • 1Division of Organogenesis and Regeneration, Medical Institute of Bioregulation, Kyushu University, Fukuoka, 812-8582, Japan.

Scientific Reports
|December 15, 2023
PubMed
Summary

Direct reprogramming can convert somatic cells into others. This study found induced intestinal stem cells (iISCs) have similar epigenomic states to normal ISCs, validating iISC safety for medical use.

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