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Association between human blood metabolome and the risk of hypertension

Nannan Dai1, Yujuan Deng2,3, Baishi Wang4

  • 1The Eco-city Hospital of Tianjin Fifth Central Hospital, Tianjin, 300467, China. dairuiaiai@126.com.

BMC Genomic Data
|December 15, 2023
PubMed

Insights

This study identifies key blood metabolites linked to high blood pressure (hypertension). Findings suggest these metabolites could be future targets for developing new hypertension treatments.

Area of Science:

  • Metabolomics
  • Genetics
  • Cardiovascular Health

Background:

  • Hypertension (high blood pressure) is a widespread, often asymptomatic condition.
  • Understanding the link between metabolites and blood pressure is crucial for intervention.

Purpose of the Study:

  • To investigate the causal relationship between blood metabolites and blood pressure (diastolic and systolic).
  • To explore the potential of metabolites as therapeutic targets for hypertension.

Main Methods:

  • Utilized two-sample Mendelian Randomization (MR) analysis.
  • Analyzed genome-wide association study (GWAS) data for 1,091 individuals.
  • Examined summary statistics for diastolic blood pressure (DBP) and systolic blood pressure (SBP) from 757,601 participants.

Main Results:

  • Identified twelve metabolites associated with DBP and twenty-two with SBP.
  • Four metabolites showed robust associations with blood pressure.
  • Reverse MR indicated blood pressure influences specific metabolite levels, such as decreasing tricosanoyl sphingomyelin and increasing 2-hydroxyhippurate.

Conclusions:

  • Blood metabolites are significantly associated with blood pressure levels.
  • These identified metabolites represent potential novel targets for hypertension management and treatment.

Keywords:
Diastolic blood pressureHypertensionMendelian randomizationSystolic blood pressure

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