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Electroretinography and suicidal behaviors: a systematic review
Mark Mohan Kaggwa1,2,3, Sebastien Prat4,5, Arianna Davids5
1Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada. kmarkmohan@gmail.com.
BMC Psychiatry
|December 15, 2023
Summary
Electroretinogram (ERG) studies reveal altered wave patterns in individuals with suicidal behaviors, including reduced b-wave amplitude and decreased b-a amplitude ratio. Further research is needed to confirm these electrophysiological findings.
Area of Science:
- Neuroscience
- Ophthalmology
- Psychiatry
Background:
- Electroretinogram (ERG) is a key tool for understanding the electrophysiological basis of mental health conditions, including suicidal behaviors.
- Existing research indicates specific ERG alterations in individuals with a history of suicidal behaviors, but a comprehensive review is lacking.
Approach:
- This review systematically analyzed existing literature on ERG findings in relation to suicidal behaviors.
- The study provides an overview of the theoretical underpinnings of ERG and relevant neurotransmitters, followed by a synthesis of empirical findings.
Key Points:
- Most studies reported normal a-wave amplitude and implicit time, but decreased latency in individuals with suicidal behaviors.
- Reduced b-wave amplitude and increased implicit time and latency were observed.
- The b-a amplitude ratio and oscillatory potentials were found to be decreased.
Conclusions:
- While certain ERG correlates of suicidal behaviors have been identified, the findings are based on limited studies.
- There is a critical need for large-scale, methodologically rigorous studies to validate these electrophysiological markers and facilitate clinical application.
