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Multiplexed Immunofluorescence Analysis and Quantification of Intratumoral PD-1+ Tim-3+ CD8+ T Cells
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Relationship between TIM3 Expression on Peripheral T Lymphocytes and Post-Stroke Depression.

Qifen Mao1, Peng Zhang2, Weicui Qi3

  • 1Department of Clinical Laboratory, Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang, 310012, China.

Iranian Journal of Immunology : IJI
|December 16, 2023
PubMed
Summary

Post-stroke depression (PSD) is linked to immune dysfunction. Increased T cell immunoglobulin and mucin domain-containing protein 3 (TIM3) on CD8+ T cells correlates with PSD severity, suggesting TIM3 as a therapeutic target.

Keywords:
InterleukinMucin Domain-Containing Protein 3Post-Stroke DepressionTherapeutic TargetT Lymphocyte

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Area of Science:

  • Immunology
  • Neuroscience
  • Psychiatry

Background:

  • T cell immunoglobulin and mucin domain-containing protein 3 (TIM3) is a regulatory molecule on T cells.
  • Limited research exists on the correlation between TIM3 expression on T lymphocytes and post-stroke depression (PSD).

Purpose of the Study:

  • To investigate the relationship between TIM3 expression on peripheral T lymphocytes and PSD.

Main Methods:

  • Flow cytometry was used to examine TIM3 expression on CD3+ CD4+ and CD3+ CD8+ T lymphocytes in acute stroke patients (NPSD, PSD) and healthy controls (HC).
  • Depressive severity was assessed using the Hamilton Depression Rating Scale (HAM-D-17).
  • Serum cytokine levels (IL-1β, IL-6, IL-10, IL-18) were measured via ELISA.

Main Results:

  • PSD patients showed reduced CD3+ CD4+ T cells compared to NPSD patients and HC.
  • Both NPSD and PSD patients had increased TIM3 expression on CD3+ CD4+ T lymphocytes versus HC.
  • PSD patients exhibited higher TIM3 expression on CD3+ CD8+ T lymphocytes, positively associated with HAM-D scores.

Conclusions:

  • PSD patients demonstrate immune dysfunction.
  • TIM3 expression on peripheral CD3+ CD8+ T lymphocytes is linked to PSD severity.
  • TIM3 may be a potential therapeutic target for PSD.