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Related Concept Videos

Attention-Deficit/Hyperactivity Disorder01:30

Attention-Deficit/Hyperactivity Disorder

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Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
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Functional Brain Systems: Reticular Formation01:13

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The reticular formation is a complex network of gray and white matter located within the brainstem extending from the medulla to the midbrain.
Within the reticular formation, there are several distinct nuclei that can be classified into three broad categories. The Raphe nuclei are located along the midline of the brainstem. They are primarily known for their role in synthesizing and releasing serotonin, a neurotransmitter involved in regulating mood, appetite, sleep, and circadian rhythms. The...
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Related Experiment Video

Updated: Jul 8, 2025

Event Related Potentials ERPs and other EEG Based Methods for Extracting Biomarkers of Brain Dysfunction: Examples from Pediatric Attention Deficit/Hyperactivity Disorder ADHD
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Aberrant Functional Connectivity in Core-Periphery Structure Based on WSBM in ADHD.

Dandan Li1, Dianni Hou1, Yating Zhang1

  • 1Taiyuan University of Technology, Shanxi, China.

Journal of Attention Disorders
|December 16, 2023
PubMed
Summary
This summary is machine-generated.

Attention Deficit Hyperactivity Disorder (ADHD) shows altered brain network community structure. This study reveals core-periphery structure anomalies in ADHD, offering new insights beyond modular analysis.

Keywords:
ADHDcommunity detectioncore–periphery structurefunctional connectivity

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Area of Science:

  • Neuroscience
  • Brain Network Analysis
  • Computational Psychiatry

Background:

  • Previous brain network studies in Attention Deficit Hyperactivity Disorder (ADHD) have primarily focused on modular community structure.
  • The core-periphery organization of functional connectivity (FC) in ADHD remains underexplored, potentially limiting a comprehensive understanding of network alterations.

Purpose of the Study:

  • To investigate the core-periphery community structure of brain functional connectivity in individuals with ADHD.
  • To evaluate changes in connectivity strength (CS) and apply a disruption index (DI) to characterize these core-periphery alterations.

Main Methods:

  • Utilized the weighted stochastic block model to partition functional connectivity into 10 distinct communities.
  • Defined the core-periphery structure using a core score metric.
  • Assessed changes in CS and DI to quantify alterations in the core-periphery organization.

Main Results:

  • The core community of the visual network exhibited reduced CS and a positive DI, indicating disruption.
  • The periphery community of the visual network showed enhanced CS.
  • Increased CS and a negative DI were observed in interactions between core sensorimotor/visual networks and the attention network's periphery.

Conclusions:

  • Anomalies in the core-periphery community structure represent a novel perspective for understanding brain network organization in ADHD.
  • These findings suggest that ADHD involves specific disruptions in the hierarchical organization of brain networks, impacting core and peripheral community interactions.