Related Experiment Video
Updated: Jul 8, 2025
Isolation of Culturable Yeasts and Molds from Soils to Investigate Fungal Population Structure
Published on: May 27, 2022
The first report of Apiotrichum mycotoxinivorans isolation from human cerebrospinal fluid
Xiuyun Li1,2, Dong Wang1, Mingju Hao3
1Maternal and Child Health Development Research Center, Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan, 250014, China.
Abstract:
Fungal infections due to Apiotrichum mycotoxinivorans are clinically rare. Here, we report a case of invasive blood and cerebrospinal fluid infection by Apiotrichum mycotoxinivorans in a girl with B-cell acute lymphoblastic leukemia. This is the first report of the isolation of Apiotrichum mycotoxinivorans from human cerebrospinal fluid. MRI features of meningitis caused by this fungus are presented. Three small isoquinoline alkaloids inhibited the growth of this rare fungus in vitro, providing a starting point for the application of natural products to treat this highly fatal fungal infection. Our case presentation confirms Apiotrichum mycotoxinivorans as a potential emerging pathogen in patients with hematological malignancy undergoing chemotherapy.
Insights
Apiotrichum mycotoxinivorans, a rare fungus, caused invasive infections in a leukemia patient. This study highlights its potential as an emerging pathogen and explores natural products for treatment.
Area of Science:
- Mycology
- Infectious Diseases
- Hematology
Background:
- Fungal infections caused by Apiotrichum mycotoxinivorans are rare in clinical settings.
- Patients with hematological malignancies undergoing chemotherapy are particularly vulnerable to opportunistic infections.
