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Published on: April 28, 2019
Association of cardiovascular disease with severe dengue: A systematic review and meta-analysis
Bijaya Kumar Padhi1, Mahalaqua Nazli Khatib2, Shilpa Gaidhane3
1Department of Community Medicine and School of Public Health, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India.
Insights
Individuals with cardiovascular disease (CVD) have a significantly higher risk of developing severe dengue. Close monitoring and targeted interventions are crucial for these patients upon dengue diagnosis to prevent severe outcomes.
Area of Science:
- Epidemiology
- Infectious Diseases
- Cardiology
Background:
- Cardiovascular disease (CVD) and dengue represent significant global health burdens.
- Pre-existing CVD may increase the risk of severe dengue outcomes, necessitating further investigation.
Approach:
- Systematic review and meta-analysis of 5 studies including 274,576 dengue patients.
- Literature search conducted across multiple databases up to November 25, 2023.
- Quality assessment using the Newcastle-Ottawa Scale and pooled Relative Risk (RR) calculation using R software.
Key Points:
- Meta-analysis revealed a significant association between CVD and increased risk of severe dengue (RR = 2.71, 95% CI: 1.03 to 7.10).
- Substantial heterogeneity (I² = 79%) was observed among the included studies, indicating variability in findings.
- The findings highlight a critical intersection between cardiovascular health and dengue severity.
Conclusions:
- Evidence suggests a notable association between cardiovascular disease and severe dengue.
- Individuals with pre-existing CVD require vigilant monitoring and tailored interventions when diagnosed with dengue.
- Proactive management strategies are essential to mitigate severe dengue outcomes in patients with cardiovascular disease.
Background:
Cardiovascular disease (CVD) and dengue are both significant global health concerns, and their intersection presents a growing clinical challenge. Emerging evidence suggests that individuals with pre-existing CVD may face an elevated risk of severe dengue outcomes. The present study aims to perform a systematic review to assess the relationship between CVD and the severity of dengue.
Methods:
We conducted a literature search across multiple databases from inception to November 25, 2023. Primary studies reporting the number of dengue patients with CVD in severe dengue and non-severe dengue groups were included. Quality assessment was performed using the Newcastle-Ottawa Scale, and a meta-analysis was conducted using R software version 4.2 to determine the pooled Relative Risk (RR). The study protocol has been registered in PROSPERO.
Results:
Based on data from 5 studies involving 274,576 dengue patients, our meta-analysis revealed a significant association between CVD and an increased risk of severe dengue, with a calculated RR of 2.71 (95 % CI: 1.03 to 7.10). However, substantial heterogeneity was observed among the included studies (I2 = 79 %).
Conclusion:
The current evidence suggests an association between CVD and severe dengue, emphasizing the importance of closely monitoring individuals with pre-existing cardiovascular disease and providing them with targeted interventions upon dengue diagnosis to mitigate the risk of severe outcomes.
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