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Related Experiment Video

Updated: Jul 8, 2025

Methylated RNA Immunoprecipitation Assay to Study m5C Modification in Arabidopsis

Methylated RNA Immunoprecipitation Assay to Study m5C Modification in Arabidopsis

Published on: May 14, 2020

The rise of epitranscriptomics: recent developments and future directions.

Jonas Cerneckis¹, Guo-Li Ming², Hongjun Song³

¹Department of Neurodegenerative Diseases, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA; Irell & Manella Graduate School of Biological Sciences, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA.

Trends in Pharmacological Sciences

|December 16, 2023

Summary

Epitranscriptomics, the study of reversible RNA modifications like N6-methyladenosine (m6A), is rapidly advancing. New detection methods and therapeutic strategies are emerging for cancer and other diseases.

Keywords:

N(6)-methyladenosine RNA modifications drug development epitranscriptomics machine learning nanopore sequencing pseudouridine

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Last Updated: Jul 8, 2025

Methylated RNA Immunoprecipitation Assay to Study m5C Modification in Arabidopsis

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Published on: May 14, 2020

Exploring m6A and m5C Epitranscriptomes upon Viral Infection: an Example with HIV

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Published on: March 5, 2022

High-throughput Screening for Chemical Modulators of Post-transcriptionally Regulated Genes

High-throughput Screening for Chemical Modulators of Post-transcriptionally Regulated Genes

Published on: March 3, 2015

Area of Science:

Epitranscriptomics
Molecular Biology
Genomics

Background:

The field of epitranscriptomics has expanded significantly with the discovery of reversible RNA modifications, particularly N6-methyladenosine (m6A).
Mapping RNA modifications across the transcriptome and understanding their role in disease are crucial for mechanistic insights and drug discovery.

Purpose of the Study:

To review recent advancements in RNA modification detection methods.
To explore the application of these methods for novel epitranscriptomic insights.
To highlight drug discovery efforts and emerging strategies for epitranscriptomic engineering.

Main Methods:

Review of recent literature on RNA modification detection techniques.
Analysis of current drug discovery approaches targeting the epitranscriptome.
Discussion of emerging technologies for epitranscriptome engineering.

Main Results:

Significant progress in RNA modification detection methods enables comprehensive transcriptome-wide mapping.
Advancements facilitate deeper understanding of epitranscriptome roles in disease.
Emerging epitranscriptomic therapeutics show promise for cancer treatment.

Conclusions:

New detection methods are revolutionizing epitranscriptomics research.
Targeting the epitranscriptome offers a promising avenue for therapeutic development.
Engineering the epitranscriptome presents a novel approach to study RNA modification effects.