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High SNHG expression may predict a poor lung cancer prognosis based on a meta-analysis
Guo-Yi Shen1, Rong-Zhi Huang1, Shao-Bin Yang1
1Department of Cardiothoracic Surgery, Zhangzhou Affiliated Hospital of Fujian Medical University, No. 59, Shengli Road, Zhangzhou City, Zhangzhou, Fujian, 363000, China.
BMC Cancer
|December 16, 2023
Summary
High expression of small nucleolar RNA host genes (SNHGs) in lung cancer is linked to poorer survival outcomes. These SNHGs show potential as prognostic markers and therapeutic targets for lung cancer.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Small nucleolar RNA host genes (SNHGs) are increasingly recognized for their dysregulation in lung cancer.
- Abnormal SNHG expression correlates significantly with lung cancer patient prognosis.
Approach:
- A meta-analysis was conducted on forty publications involving 2205 lung cancer patients.
- Data on overall survival (OS), progression-free survival (PFS), TNM stage, lymph node metastasis (LNM), and tumor size were extracted and analyzed.
- Hazard ratios (HRs) and odds ratios (ORs) with 95% confidence intervals (CIs) were pooled to assess the relationship between SNHG expression and lung cancer outcomes.
Key Points:
- High SNHG expression was significantly associated with poor OS (HR: 1.890), disease-free survival (DFS) (HR: 2.31), and PFS (HR: 2.01).
- Increased SNHG expression correlated with advanced TNM stage (OR: 1.509), increased risk of lymph node metastasis (OR: 1.540), and larger tumor size (OR: 1.509).
- Sensitivity and publication bias analyses confirmed the reliability and robustness of the findings.
Conclusions:
- The study concludes that most SNHGs are upregulated in lung cancer tissues.
- High SNHG expression is a predictor of poor survival in lung cancer patients.
- SNHGs represent potential prognostic markers and therapeutic targets for lung cancer.
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