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Published on: July 17, 2020
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Chiral cysteine-copper ion-based assemblies for improved phototherapy.
Xiaohuan Sun1, Qianyun Ye1, Yuanyuan Liang2
1School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, China.
Journal of Colloid and Interface Science
|December 17, 2023
Summary
Chirality significantly impacts cancer phototherapy. D-cysteine-copper nanoparticles show enhanced cellular uptake and anti-tumor effects compared to L-cysteine-copper nanoparticles when used with indocyanine green for photothermal and photodynamic therapy.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Cancer Therapy
Background:
- Phototherapy, including photothermal and photodynamic approaches, is a promising cancer treatment.
- Optimizing phototherapy requires understanding factors influencing its efficacy.
- Chirality's role in nanoparticle-based cancer therapies remains an area for exploration.
Purpose of the Study:
- To investigate the influence of chirality on L/d-cysteine-copper ion nanoparticles for cancer phototherapy.
- To evaluate the interaction, cellular uptake, and anti-tumor efficacy of chiral nanoparticles.
- To engineer nanoparticle drug delivery systems for enhanced phototherapy.
Main Methods:
- Construction of L/d-cysteine-copper ion (Cu2+) chiral nanoparticles via coordination complex assembly.
- Assessment of nanoparticle binding affinity to chiral liposomes.
- Evaluation of cellular internalization by Hela cells.
- Encapsulation of indocyanine green (ICG) into nanoparticles for combined photothermal and photodynamic therapy.
- Comparison of anti-tumor effects of L/d-Cys-Cu2+-ICG nanoparticles under laser irradiation.
Main Results:
- D-cysteine-copper ion nanoparticles exhibited over three times stronger binding affinity to chiral liposomes than L-cysteine-copper ion nanoparticles.
- D-cysteine-copper ion nanoparticles demonstrated significantly higher cellular uptake efficiency in Hela cells compared to L-cysteine-copper ion nanoparticles.
- Both L/d-Cys-Cu2+-ICG nanoparticles showed similar photothermal performance and singlet oxygen generation.
- D-cysteine-copper ion-indocyanine green nanoparticles achieved superior anti-tumor effects due to enhanced cellular uptake.
Conclusions:
- Chirality plays a critical role in the efficacy of nanoparticle-based phototherapy.
- Chirality-dependent cellular uptake significantly influences anti-tumor outcomes.
- These findings offer new strategies for designing chiral nanoparticles for advanced cancer therapeutics.
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