Flexible molecularly imprinted glucose sensor based on graphene sponge and Prussian blue

Area of Science:

• Electrochemistry
• Materials Science
• Biosensors

Background:

• Flexible glucose sensors are crucial for diabetes management.
• Enhancing sensitivity and stability of these sensors remains a key challenge.
• Molecular imprinting offers a promising route for selective analyte detection.

Purpose of the Study:

• To develop a highly sensitive and stable flexible glucose sensor.
• To improve charge transfer in molecularly imprinted sensors using graphene sponge and Prussian blue.
• To evaluate the sensor's performance for practical glucose monitoring.

Main Methods:

• Fabrication of a flexible glucose sensor using 3-aminophenylboronic acid and pyrrole on a carbon tri-electrode.
• Modification of the electrode with graphene sponge (GS) and Prussian blue (PB) to enhance charge transfer.
• Electrochemical characterization using electrochemical impedance spectroscopy, cyclic voltammetry, and differential pulse voltammetry.

Main Results:

• GS and PB modification significantly reduced charge transfer impedance and increased redox current.
• The sensor achieved a high sensitivity of 25.81 µA⋅log_e (µM)^-1⋅cm^-2 for glucose detection.
• A low detection limit of 1.08 μM was obtained, with good stability across varying pH and minimal interference from common biomolecules.

Conclusions:

• The developed flexible glucose sensor exhibits high sensitivity, specificity, and stability.
• Graphene sponge and Prussian blue effectively enhance sensor performance.
• This work contributes to the advancement of wearable electrochemical biosensors for continuous glucose monitoring.