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Flow Void Analysis Using Different Thresholding Methods on a Choriocapillaris Optical Coherence Tomography
Young Joo Lee1, Soon-Young Hwang2, Cheolmin Yun1
1Department of Ophthalmology, Korea University College of Medicine, Seoul, Korea.
Korean Journal of Ophthalmology : KJO
|December 17, 2023
Summary
Different binarization methods impact choriocapillaris optical coherence tomography angiography (OCTA) flow void analysis. While methods vary, results show good correlation, suggesting careful consideration for accurate interpretation.
Area of Science:
- Ophthalmology
- Medical Imaging
- Biomedical Engineering
Background:
- Choriocapillaris (CC) imaging is crucial for diagnosing retinal diseases.
- Optical coherence tomography angiography (OCTA) provides high-resolution visualization of CC vasculature.
- Standardized analysis of CC OCTA images is essential for reliable clinical interpretation.
Purpose of the Study:
- To evaluate the impact of various thresholding techniques on choriocapillaris OCTA image analysis.
- To compare flow void characteristics derived from different binarization methods.
- To assess the correlation between global and auto local thresholding in CC OCTA.
Main Methods:
- 42 healthy subject CC OCTA images (3x3mm) were analyzed using ImageJ.
- Images were processed with global and Phansalkar auto local thresholding methods.
- Flow void parameters (area, number, size) were compared across methods.
Main Results:
- Significant differences in flow void area, number, and size were observed across binarization methods (p < 0.001).
- High intraclass correlations (>0.929) were found between global and auto local thresholding methods.
- Flow void features varied based on the binarization approach used.
Conclusions:
- Binarization methods significantly influence choriocapillaris OCTA flow void characteristics.
- Despite variations, good correlation exists between different thresholding techniques.
- Consideration of binarization method is critical for accurate analysis of CC OCTA images.
