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Intelligent Delivery Systems in Tumor Metabolism Regulation: Exploring the Path Ahead

Xuwen Li1, Tao Sun1, Chen Jiang1

  • 1Department of Pharmaceutics, School of Pharmacy, Fudan University, Key Laboratory of Smart Drug Delivery, Ministry of Education, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Shanghai, 201203, China.

Advanced Materials (Deerfield Beach, Fla.)
|December 17, 2023
PubMed

Insights

Targeting cancer metabolism is key for tumor control. This review explores intelligent drug delivery systems for multi-level regulation of the tumor metabolic microenvironment, offering a new cancer treatment paradigm.

Area of Science:

  • Oncology
  • Metabolic Engineering
  • Drug Delivery Systems

Background:

  • Cancer metabolism significantly influences tumor initiation, progression, and resistance.
  • Tumor metabolic networks are complex and interconnected with signaling pathways.
  • The tumor microenvironment presents unique characteristics for therapeutic intervention.

Purpose of the Study:

  • To summarize key features of tumor metabolism.
  • To review advancements in intelligent drug delivery systems for cancer.
  • To propose a novel paradigm for cancer treatment through metabolic microenvironment regulation.

Main Methods:

  • Literature review of tumor metabolism.
  • Analysis of intelligent drug delivery systems.
  • Exploration of multi-level modulation strategies for the tumor microenvironment.

Main Results:

  • Identified numerous interconnected therapeutic targets within tumor metabolic networks.
  • Highlighted the efficacy of drug delivery systems in modulating the tumor microenvironment.
  • Demonstrated the potential for multi-level regulation of cancer metabolism.

Conclusions:

  • Understanding tumor metabolism is crucial for developing effective cancer therapies.
  • Intelligent drug delivery systems offer a promising approach for multi-dimensional cancer control.
  • Multi-level metabolic microenvironment regulation represents a novel paradigm for cancer treatment.
Keywords:
intelligent delivery systemsmetabolism regulationnanomedicinetumor metabolism

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