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Extracorporeal photopheresis: Is one ounce of blood enough? Case reports

Irina Kumukova1,2, Elena Kurnikova1, Pavel Trakhtman1

  • 1Department of Transfusion Medicine, Rogachev Federal Scientific and Clinical Centre of Pediatric Hematology Oncology and Immunology, Moscow, Russia.

Pediatric Blood & Cancer
|December 18, 2023
PubMed

Extracorporeal photopheresis (ECP) has proven effective in the treatment of several diseases, including acute and chronic graft-versus-host disease (GVHD) after allogeneic hematopoietic stem cell transplantation. In its standard version, ECP requires leukapheresis to obtain a fraction of mononuclear cells. The possibility of using leukapheresis is limited by the requirements for vascular access and the somatic status of the patient. We have developed a new ECP method that does not require leukapheresis. This paper presents a description of two clinical cases of severe refractory GVHD treated by micro-ECP.

Keywords:
extracorporeal photopheresisgraft-versus-host diseasephotopheresis

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