Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Biological Methods for Microbial Control

Biological Methods for Microbial Control

Biological agents offer an effective means of controlling microbial growth by leveraging natural processes like predation, competition, and the secretion of antimicrobial substances.Predatory bacteria such as Bdellovibrio species target and kill pathogens like Salmonella and E. coli. They are widely used in poultry farms to control infections. Myxococcus species help combat plant-pathogenic fungi. These naturally occurring predators serve as eco-friendly alternatives to chemical pesticides and...

Gene Regulation in Microbial Communities: Quorum Sensing

Gene Regulation in Microbial Communities: Quorum Sensing

Quorum sensing is a mechanism of bacterial communication that enables coordinated gene expression in response to changes in population density. This facilitates collective behaviors that enhance survival, resource acquisition, and ecological adaptation. This process relies on small signaling molecules called autoinducers that accumulate as bacterial populations grow. When a critical threshold concentration of autoinducers is reached, bacterial cells collectively modify gene expression,...

Production of Antibiotics

Production of Antibiotics

Penicillin, one of the earliest and most widely used antibiotics, is produced industrially by the filamentous fungus Penicillium chrysogenum. Large stirred-tank bioreactors ranging from tens to hundreds of thousands of liters maintain tightly controlled temperature, pH, and dissolved oxygen conditions to support fungal metabolism and maximize antibiotic yield. Penicillin is a secondary metabolite, synthesized primarily during the stationary growth phase, which requires a carefully managed...

Clinical Significance of Antibiotic Resistance

Clinical Significance of Antibiotic Resistance

Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Corrigendum to "Xanthoxylin alleviates dextran sulfate sodium (DSS)-induced colitis by targeting macrophage infiltration via the tumor necrosis factor (TNF)/nuclear factor-kappa B (NF-κB) signaling pathway" [Phytomedicine 153:157971 (2026) PMID: 41720014].

Phytomedicine : international journal of phytotherapy and phytopharmacology·2026

Same author

Unveiling the landscape of Mottness and its proximity to superconductivity in 4Hb-TaS<sub>2</sub>.

Nature communications·2026

Same author

Subinhibitory Concentrations of Rifampicin Synergize with Linezolid to Delay Resistance Evolution in Clinical Methicillin-Resistant Staphylococcus Aureus.

Microorganisms·2026

Same author

The ocular surface consequences of lacrimal gland loss are life-stage dependent.

The ocular surface·2026

Same author

A retrospective observational study of oral ivarmacitinib and narrow-band ultraviolet-B in refractory progressive vitiligo.

Journal of the American Academy of Dermatology·2026

Same author

Real-world treatment patterns, resource use, and costs in human epidermal growth factor receptor 2-negative advanced gastric/gastroesophageal junction cancer in the United States in the immune checkpoint inhibitor era.

Journal of managed care & specialty pharmacy·2026

Search research articles

Related Experiment Video

Updated: Jul 27, 2026

Engineering Adherent Bacteria by Creating a Single Synthetic Curli Operon

Engineering Adherent Bacteria by Creating a Single Synthetic Curli Operon

Published on: November 16, 2012

Microbial cell factories using Paenibacillus: status and perspectives.

Panhong Yuan¹, Ziyan Chen¹, Mengtao Xu¹

¹College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou, Zhejiang, China.

Critical Reviews in Biotechnology

|December 18, 2023

Summary

Paenibacillus bacteria, recognized as safe, offer agricultural and industrial benefits. Advances in genetic tools are unlocking their potential as microbial chassis for biomanufacturing, expanding applications in enzymes, bioremediation, and antimicrobials.

Keywords:

Paenibacillus bioresource genetic manipulation system microbial chassis restriction modification system

More Related Videos

Microfluidic Picoliter Bioreactor for Microbial Single-cell Analysis: Fabrication, System Setup, and Operation

Microfluidic Picoliter Bioreactor for Microbial Single-cell Analysis: Fabrication, System Setup, and Operation

Published on: December 6, 2013

Rapid, Affordable, and Uncomplicated Production of Bacterial Cell-free Lysate

Rapid, Affordable, and Uncomplicated Production of Bacterial Cell-free Lysate

Published on: October 29, 2021

Related Experiment Videos

Last Updated: Jul 27, 2026

Engineering Adherent Bacteria by Creating a Single Synthetic Curli Operon

Engineering Adherent Bacteria by Creating a Single Synthetic Curli Operon

Published on: November 16, 2012

Microfluidic Picoliter Bioreactor for Microbial Single-cell Analysis: Fabrication, System Setup, and Operation

Microfluidic Picoliter Bioreactor for Microbial Single-cell Analysis: Fabrication, System Setup, and Operation

Published on: December 6, 2013

Rapid, Affordable, and Uncomplicated Production of Bacterial Cell-free Lysate

Rapid, Affordable, and Uncomplicated Production of Bacterial Cell-free Lysate

Published on: October 29, 2021

Area of Science:

Microbiology
Biotechnology
Synthetic Biology

Background:

Paenibacillus, a Generally Recognized As Safe (GRAS) bacterium, possesses diverse applications in agriculture, medicine, industry, and environmental remediation.
These rhizobacteria promote plant growth, degrade toxins, and produce valuable enzymes and antimicrobial peptides.
Limited genetic manipulation tools historically restricted the full exploitation of Paenibacillus bioresources.

Purpose of the Study:

To review the applications of Paenibacillus bioproducts.
To discuss recent advancements in genetic manipulation systems for Paenibacillus.
To highlight future challenges and the potential of Paenibacillus as a microbial chassis for biomanufacturing.

Main Methods:

Review of existing literature on Paenibacillus applications and genetic tools.
Analysis of advancements in genetic manipulation techniques, including shuttle plasmids, promoters, and CRISPR.
Examination of developing genetic transformation systems like penicillin-mediated transformation, electroporation, and magnesium-mediated transformation.

Main Results:

Significant progress has been made in developing genetic manipulation tools and transformation systems for Paenibacillus.
These advancements are enabling Paenibacillus to be utilized as a microbial chassis for biomanufacturing.
Expanded applications include industrial enzymes, bioremediation, bioadsorption, surfactants, and antibacterial agents.

Conclusions:

Paenibacillus holds immense potential as a microbial chassis for mining bioresources.
Continued development of genetic manipulation systems is crucial for realizing this potential.
The genus offers promising avenues for sustainable biomanufacturing and diverse industrial applications.